Portal hypertension is associated with poor outcome of transarterial chemoembolization in patients with hepatocellular carcinoma

Objectives To determine whether clinically relevant portal hypertension (CRPH) influences outcome and whether it may serve as a prognostic marker in patients treated with transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Methods One hundred and forty-seven patients underwent...

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Bibliographic Details
Published in:European radiology 2018-05, Vol.28 (5), p.2184-2193
Main Authors: Choi, Jin Woo, Chung, Jin Wook, Lee, Dong Ho, Kim, Hyo-Cheol, Hur, Saebeom, Lee, Myungsu, Jae, Hwan Jun
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Carcinoma, Hepatocellular - therapy
Catheterization
Catheterization, Peripheral - methods
Chemoembolization
Chemoembolization, Therapeutic - adverse effects
Diagnostic Radiology
Female
Grading
Hazards
Hemorrhage
Hepatocellular carcinoma
Humans
Hypertension
Hypertension, Portal - complications
Hypertension, Pulmonary - etiology
Hypertension, Pulmonary - physiopathology
Iliac Artery
Imaging
Infusions, Intra-Arterial
Internal Medicine
Interventional
Interventional Radiology
Liver cancer
Liver Neoplasms - therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Patients
Pulmonary Wedge Pressure - physiology
Radiology
Regression analysis
Retrospective Studies
Treatment Outcome
Tumors
Ultrasound
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Summary:Objectives To determine whether clinically relevant portal hypertension (CRPH) influences outcome and whether it may serve as a prognostic marker in patients treated with transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Methods One hundred and forty-seven patients underwent conventional TACE as a first-line treatment for a single HCC. CRPH was graded as 0, 1, or 2. The influence of CRPH, together with other factors, on local tumour progression (LTP) and overall survival (OS) were analysed using Cox proportional hazards regression. Results A higher CRPH grade (grade 1, p  = 0.005, hazard ratio [HR] = 3.282; grade 2, p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-017-5145-9