Bilateral preictal signature of phase-amplitude coupling in canine epilepsy

•Statistically significant difference in PAC between preictal and interictal periods.•PAC change is strongest for coupling between delta phase and high-gamma amplitude.•Bilateral presence of PAC change infers that preictal phase is not restricted to SOZ.•Cross-Frequency Phase-Amplitude Coupling is a...

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Bibliographic Details
Published in:Epilepsy research 2018-01, Vol.139, p.123-128
Main Authors: Gagliano, Laura, Bou Assi, Elie, Nguyen, Dang K., Rihana, Sandy, Sawan, Mohamad
Format: Article
Language:English
Subjects:
Algorithms
Animals
Brain - physiopathology
Cross frequency coupling
Dog Diseases - diagnosis
Dog Diseases - physiopathology
Dogs
Electrocorticography
Epilepsy
Epilepsy, Temporal Lobe - diagnosis
Epilepsy, Temporal Lobe - physiopathology
Epilepsy, Temporal Lobe - veterinary
Feature extraction
Phase amplitude coupling
Preictal state
Seizure forecasting
Seizures - diagnosis
Seizures - physiopathology
Seizures - veterinary
Signal Processing, Computer-Assisted
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Summary:•Statistically significant difference in PAC between preictal and interictal periods.•PAC change is strongest for coupling between delta phase and high-gamma amplitude.•Bilateral presence of PAC change infers that preictal phase is not restricted to SOZ.•Cross-Frequency Phase-Amplitude Coupling is a precursor of epileptic seizures. Seizure forecasting would improve the quality of life of patients with refractory epilepsy. Although early findings were optimistic, no single feature has been found capable of individually characterizing brain dynamics during transition to seizure. Cross-frequency phase amplitude coupling has been recently proposed as a precursor of seizure activity. This work evaluates the existence of a statistically significant difference in mean phase amplitude coupling distribution between the preictal and interictal states of seizures in dogs with bilaterally implanted intracranial electrodes. Results show a statistically significant change (p
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2017.11.009