Genetically deprived vitamin D exposure predisposes to atrial fibrillation

Low vitamin D level is associated with atrial fibrillation (AF) and may be implicated in its pathogenesis. We studied single nucleotide polymorphisms (SNPs) of vitamin D mechanistic pathways and serum 25-hydroxyvitamin D [25(OH)D] levels in an age- and gender-matched case-control study (controls wit...

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Published in:Europace (London, England) England), 2017-12, Vol.19 (suppl_4), p.iv25-iv31
Main Authors: Chan, Yap-Hang, Yiu, Kai-Hang, Hai, Jo Jo, Chan, Pak-Hei, Lam, Tai-Hing, Cowling, Ben J, Sham, Pak-Chung, Lau, Chu-Pak, Lam, Karen Siu-Ling, Siu, Chung-Wah, Tse, Hung-Fat
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - diagnosis
Atrial Fibrillation - etiology
Biomarkers - blood
Case-Control Studies
China
Coronary Disease - complications
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Prognosis
Risk Assessment
Risk Factors
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - diagnosis
Vitamin D Deficiency - genetics
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Summary:Low vitamin D level is associated with atrial fibrillation (AF) and may be implicated in its pathogenesis. We studied single nucleotide polymorphisms (SNPs) of vitamin D mechanistic pathways and serum 25-hydroxyvitamin D [25(OH)D] levels in an age- and gender-matched case-control study (controls without AF: mean age 68.6 ± 8.7 years, female 25%; n = 1019; with AF: mean age 69.7 ± 9.5 years, female 30%; n = 156) recruited from a Chinese clinical cohort of patients with stable coronary artery disease. Twelve SNPs involved in the vitamin D mechanistic pathways were studied [biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349; activation: rs2060793, rs1993116; vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and vitamin D receptor: rs1544410, rs10735810]. A genetic risk score (GRS) (0-8) was constructed from SNPs associated with serum 25(OH)D as a proxy to lifelong vitamin D-deficient state. All 4 SNPs involved in the VBP/GC were significantly associated with serum 25(OH)D (rs4588, P 
ISSN:1099-5129
1532-2092
DOI:10.1093/europace/eux312