Polymorphic Variability in the Interleukin (IL)-1b Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1b Production

Interleukin (IL)-1b is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1b polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1b promoter variants...

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Bibliographic Details
Published in:The Journal of infectious diseases 2008-01, Vol.198 (8), p.1219-1226
Main Authors: Ouma, Collins, Davenport, Gregory C, Awandare, Gordon A, Keller, Christopher C, Were, Tom, Otieno, Michael F, Vulule, John M, Martinson, Jeremy, Ong'echa, John M, Ferrell, Robert E, Perkins, Douglas J
Format: Article
Language:English
Subjects:
Plasmodium falciparum
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Summary:Interleukin (IL)-1b is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1b polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1b promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level
ISSN:0022-1899
DOI:10.1086/592055