Lipid Peroxidation in Workers Exposed to Aluminium, Gallium, Indium, Arsenic, and Antimony in the Optoelectronic Industry

Objective: The objective of this study was to investigate whether exposure to aluminum, gallium, indium, arsenic, and antimony induces lipid peroxidation in humans. Methods: Whole blood and urine levels of 103 exposed electronic industry workers and 67 referents were analyzed by use of inductively c...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2006-08, Vol.48 (8), p.789-793
Main Authors: Liao, Yen-Hsiung, Hwang, Long-Chih, Kao, Jing-Shwu, Yiin, Shuenn-Jiun, Lin, Shu-Fang, Lin, Chia-Hong, Lin, Yu-Cheng, Aw, Tar-Ching
Format: Article
Language:English
Subjects:
Adult
Aluminum - blood
Aluminum - urine
Antimony - blood
Antimony - urine
Arsenic - blood
Arsenic - urine
Biological and medical sciences
Biomarkers - blood
Biomarkers - urine
Chemical and industrial products toxicology. Toxic occupational diseases
Electronics
Electronics industry
Environmental Monitoring - methods
Female
Gallium - blood
Gallium - urine
Hazardous materials
Health risk assessment
Human exposure
Humans
Indium - blood
Indium - urine
Lipid Peroxidation
Lipids
Male
Malondialdehyde - blood
Malondialdehyde - urine
Medical sciences
Metals and various inorganic compounds
Occupational Exposure - analysis
Occupational hazards
Optics and Photonics
ORIGINAL ARTICLES
Toxicity
Toxicology
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Summary:Objective: The objective of this study was to investigate whether exposure to aluminum, gallium, indium, arsenic, and antimony induces lipid peroxidation in humans. Methods: Whole blood and urine levels of 103 exposed electronic industry workers and 67 referents were analyzed by use of inductively coupled plasma mass spectrometry. Malondialdehyde (MDA), the product of lipid peroxidation, was determined by high-performance liquid chromatography. Results: The mean plasma MDA level in the 103 workers was significantly higher than that in 67 referents. The levels of MDA in the exposed workers were correlated significantly with the levels of urinary gallium and arsenic. Conclusions: Malondialdehyde as an index of lipid peroxidation can be induced by gallium and arsenic exposure. By reducing exposure to these metals, biologic effects such as lipid peroxidation may also be diminished.
ISSN:1076-2752
1536-5948
DOI:10.1097/01.jom.0000229782.71756.8e