Comparison of Adjuvant Radiation Therapy Before or After Artificial Urinary Sphincter Placement: A Multi-Institutional, Retrospective Analysis

• Published in: Urology (Ridgewood, N.J.) N.J.), 2018-03, Vol.113, p.160-165
• Main Authors: DeLay, Kenneth J., Haney, Nora M., Chiang, Jason, Stewart, Carrie, Yafi, Faysal A., Angermeier, Kenneth, Wood, Hadley, Boone, Timothy, Kavanagh, Alex G., Gretzer, Matthew, Boyd, Stuart, Loh-Doyle, Jeffrey C., Hellstrom, Wayne J.G.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Cohort Studies; Follow-Up Studies; Humans; Male; Middle Aged; Prostatectomy - adverse effects; Prostatectomy - methods; Prostatic Neoplasms - radiotherapy; Prostatic Neoplasms - surgery; Radiotherapy, Adjuvant; Retrospective Studies; Risk Assessment; Time Factors; Treatment Outcome; Urinary Incontinence, Stress - etiology; Urinary Incontinence, Stress - surgery; Urinary Sphincter, Artificial; Urodynamics
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2017.11.041

To determine if the timing of radiation therapy on artificial urinary sphincter (AUS) impacts complication rates, revision rates, and number of pads per day after placement. A retrospective review was conducted of men with prostate cancer who underwent AUS placement and radiation therapy between 1987 and 2016. Of 306 men, 292 (95.4%) received radiation before AUS placement (group 1) and 14 (4.6%) received radiation after AUS placement (group 2). Median follow-up was 30 months after AUS placement. Group 1 had 32 of 292 (11.0%) patients suffer from erosion, compared with 0 of 14 (0.0%) patients in group 2 (P = .191). None of the patients in group 2 had infection or mechanical failure. The number of patients who received revision in group 1 was 91 of 292 (31.2%) and in group 2 was 2 of 14 (14.3%) (P = .180). The number of pads used per day in group 1 before and after AUS placement was 5.24 ± 3.12 and 1.13 ± 1.31, respectively (P