Antitussive and expectorant activities of licorice and its major compounds

[Display omitted] Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin a...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2018-01, Vol.26 (1), p.278-284
Main Authors: Kuang, Yi, Li, Bin, Fan, Jingran, Qiao, Xue, Ye, Min
Format: Article
Language:English
Subjects:
Administration, Oral
Ammonia
Animals
Antitussive
Antitussive Agents - antagonists & inhibitors
Antitussive Agents - chemistry
Antitussive Agents - pharmacology
Cough
Cough - chemically induced
Cough - drug therapy
Disease Models, Animal
Dose-Response Relationship, Drug
Expectorant
Expectorants - chemistry
Expectorants - isolation & purification
Expectorants - pharmacology
Glyburide - pharmacology
Glycyrrhiza - chemistry
Herbal medicine
Licorice
Male
Methysergide - pharmacology
Mice
Mice, Inbred ICR
Molecular Structure
Phenolsulfonphthalein - metabolism
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Structure-Activity Relationship
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Summary:[Display omitted] Licorice has been used as an antitussive and expectorant herbal medicine for a long history. This work evaluated the activities of 14 major compounds and crude extracts of licorice, using the classical ammonia-induced cough model and phenol red secretion model in mice. Liquiritin apioside (1), liquiritin (2), and liquiritigenin (3) at 50 mg/kg (i.g.) could significantly decrease cough frequency by 30–78% (p 
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2017.11.046