Influence of dietary nitrate food forms on nitrate metabolism and blood pressure in healthy normotensive adults

• Published in: Nitric oxide 2018-01, Vol.72, p.66-74
• Main Authors: McDonagh, Sinead T.J., Wylie, Lee J., Webster, James M.A., Vanhatalo, Anni, Jones, Andrew M.
• Format: Article
• Language: English
• Subjects: Adult; Beta vulgaris; Blood pressure; Blood Pressure - drug effects; Cardiovascular health; Dietary nitrate; Dietary Supplements; Fruit and Vegetable Juices; Heart Rate - drug effects; Humans; Male; Nitrates - administration & dosage; Nitrates - metabolism; Nitrates - pharmacokinetics; Nitrite; Nitrites - analysis; Nitrites - metabolism; Pharmacokinetics; Saliva - chemistry
• ISSN: 1089-8603; 1089-8611
• DOI: 10.1016/j.niox.2017.12.001

Inorganic nitrate (NO3−) supplementation has been shown to improve cardiovascular health indices in healthy adults. The purpose of this study was to investigate how the vehicle of NO3− administration can influence NO3− metabolism and the subsequent blood pressure response. Ten healthy males consumed an acute equimolar dose of NO3− (∼5.76 mmol) in the form of a concentrated beetroot juice drink (BR; 55 mL), a non-concentrated beetroot juice drink (BL; 456 mL) and a solid beetroot flapjack (BF; 60 g). A drink containing soluble beetroot crystals (BC; ∼1.40 mmol NO3−) and a control drink (CON; 70 mL deionised water) were also ingested. BP and plasma, salivary and urinary [NO3−] and [NO2−] were determined before and up to 24 h after ingestion. All NO3−-rich vehicles elevated plasma, salivary and urinary nitric oxide metabolites compared with baseline and CON (P