Clinical impact of adjuvant radiation therapy delay after neoadjuvant chemotherapy in locally advanced breast cancer

and Purpose: Post-operative radiation therapy (PORT) is usually indicated for patients with breast cancer (BC) after neoadjuvant chemotherapy (NAC) and surgery. However, the optimal timing to initiation of PORT is currently unknown. We retrospectively evaluated data from patients with BC who receive...

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Published in:Breast (Edinburgh) 2018-04, Vol.38, p.39-44
Main Authors: Silva, Saulo Brito, Pereira, Allan Andresson Lima, Marta, Gustavo Nader, de Barros Lima, Kennya Medeiros Lopes, de Freitas, Thiago Brasileiro, Matutino, Adriana Reis Brandão, de Azevedo Souza, Manoel Carlos Leonardi, de Azevedo, Renata Gondim Meira Velame, de Viveiros, Pedro Antonio Hermida, da Silva Lima, Julianne Maria, Filassi, José Roberto, de Andrade Carvalho, Heloísa, Piato, José Roberto Morales, Mano, Max S.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast neoplasms
Breast Neoplasms - drug therapy
Breast Neoplasms - mortality
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Chemotherapy
Chemotherapy, Adjuvant - methods
Disease-Free Survival
Female
Follow-Up Studies
Humans
Mastectomy - statistics & numerical data
Middle Aged
Neoadjuvant Therapy - methods
Overall survival
Radiation therapy
Radiotherapy, Adjuvant - methods
Retrospective Studies
Survival Rate
Time Factors
Time-to-treatment
Treatment Outcome
Young Adult
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Summary:and Purpose: Post-operative radiation therapy (PORT) is usually indicated for patients with breast cancer (BC) after neoadjuvant chemotherapy (NAC) and surgery. However, the optimal timing to initiation of PORT is currently unknown. We retrospectively evaluated data from patients with BC who received PORT after NAC and surgery at our institution from 2008 to 2014. Patients were categorized into three groups according to the time between surgery and PORT: 16 weeks. A total of 581 patients were included; 74% had clinical stage III. Forty-three patients started PORT within 8 weeks, 354 between 8 and 16 weeks and 184 beyond 16 weeks from surgery. With a median follow-up of 32 months, initiation of PORT up to 8 weeks after surgery was associated with better disease-free survival (DFS) (
ISSN:0960-9776
1532-3080
DOI:10.1016/j.breast.2017.11.012