Maternal immune activation in neurodevelopmental disorders

Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental di...

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Bibliographic Details
Published in:Developmental dynamics 2018-04, Vol.247 (4), p.588-619
Main Authors: Solek, Cynthia M., Farooqi, Nasr, Verly, Myriam, Lim, Tony K., Ruthazer, Edward S.
Format: Article
Language:English
Subjects:
Activation
Animal models
Autism
autism spectrum disorder
Basic converters
Disorders
Immune response
maternal immune activation
Mental disorders
microglia
Neurodevelopmental disorders
Schizophrenia
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Summary:Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. Developmental Dynamics 247:588–619, 2018. © 2017 Wiley Periodicals, Inc. Key Findings Presents evidence linking maternal immune activation to autism spectrum disorder and schizophrenia. Explains how dysregulation of microglial function may be involved in neurodevelopmental disorders. Summarizes supporting evidence from pre‐clinical animal models of maternal immune activation.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.24612