Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes

Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H 2O 2/TFE in presence of MeReO 3 as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of thes...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2008-02, Vol.18 (4), p.1446-1449
Main Authors: Atheaya, Himanshu, Khan, Shabana I., Mamgain, Ritu, Rawat, Diwan S.
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarial activity
Antimalarials - chemical synthesis
Antimalarials - chemistry
Antimalarials - pharmacology
Antiparasitic agents
Benzene Derivatives - chemical synthesis
Benzene Derivatives - chemistry
Benzene Derivatives - pharmacology
Biological and medical sciences
Calorimetry, Differential Scanning
Chloroquine - pharmacology
Cytotoxicity
Differential scanning calorimetry
Drug Stability
Erythrocytes - parasitology
Hot Temperature
Humans
Inhibitory Concentration 50
Malaria, Falciparum - blood
Malaria, Falciparum - drug therapy
Medical sciences
Pharmacology. Drug treatments
Plasmodium falciparum
Structure-Activity Relationship
Tetraoxane
Tetraoxanes - chemical synthesis
Tetraoxanes - chemistry
Tetraoxanes - pharmacology
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Summary:Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H 2O 2/TFE in presence of MeReO 3 as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity without showing any cytotoxicity. Thermal stability of these compounds was studied by differential scanning calorimetry.
ISSN:0960-894X
0968-0896
1464-3405
1464-3391
DOI:10.1016/j.bmcl.2007.12.069