MicroRNA-206: The skeletal muscle-specific myomiR

MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myom...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2008-11, Vol.1779 (11), p.682-691
Main Author: McCarthy, John J.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Circadian
Fiber-type
Humans
MicroRNA
MicroRNAs - genetics
MicroRNAs - metabolism
Molecular Sequence Data
Muscle Development - genetics
Muscle, Skeletal - metabolism
Organ Specificity
Satellite cell
Skeletal muscle
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Summary:MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myo = muscle + miR = miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle.
ISSN:1874-9399
0006-3002
1876-4320
DOI:10.1016/j.bbagrm.2008.03.001