The RSPO3 gene as genetic markers for bone mass assessed by quantitative ultrasound in a population of young adults

Ultrasound bone mass measurement has been postulated as a valuable bone‐health assessment tool for primary care. The aim of this study was to analyse the possible relationship between the SPTBN1, RSPO3, CCDC170, DKK1, GPATCH1, and TMEM135 genes, with calcaneal quantitative ultrasound (QUS) in a popu...

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Bibliographic Details
Published in:Annals of human genetics 2018-05, Vol.82 (3), p.143-149
Main Authors: Correa‐Rodríguez, María, Schmidt Rio‐Valle, Jacqueline, Rueda‐Medina, Blanca
Format: Article
Language:English
Subjects:
Bone Density - genetics
Bone mass
calcaneal quantitative ultrasound
Calcaneus
Calcaneus - diagnostic imaging
Cross-Sectional Studies
Dkk1 protein
Female
Genes
Genetic Markers
Genotype
Heredity
Hip joint
Humans
Male
Polymorphism, Single Nucleotide
polymorphisms
RSPO3
Single-nucleotide polymorphism
Thrombospondins - genetics
Ultrasonic imaging
Ultrasonography
Ultrasound
Young Adult
Young adults
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Summary:Ultrasound bone mass measurement has been postulated as a valuable bone‐health assessment tool for primary care. The aim of this study was to analyse the possible relationship between the SPTBN1, RSPO3, CCDC170, DKK1, GPATCH1, and TMEM135 genes, with calcaneal quantitative ultrasound (QUS) in a population of young adults. These genes were first associated with broadband ultrasound attenuation (BUA) in the GEFOS/GENOMOS study. A cross‐sectional study was conducted on 575 individuals (mean age 20.41 ± 2.69). Bone mass at the right calcaneus was estimated by QUS. Six single‐nucleotide polymorphisms (SNPs) in SPTBN1 (rs11898505), RSPO3 (rs7741021), CCDC170 (rs4869739), DKK1 (rs7902708), TMEM135 (rs597319), and GPATCH1 (rs10416265) were selected as genetic markers based on their previous association with calcaneal QUS. After adjusting for multiple confounding factors, the only significant association with QUS in our population was found for the rs7741021 SNP in the RSPO3 gene (P = 0.006) using the dominant model of inheritance. This suggests the possible implication of the RSPO3 gene in bone mass acquisition during early adulthood.
ISSN:0003-4800
1469-1809
DOI:10.1111/ahg.12235