Loading…
Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels
Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prev...
Saved in:
| Published in: | Atherosclerosis 2018-01, Vol.268, p.152-156 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c444t-fab84eede27f36a6ee1f5cd2b33b4017347e5de84ecf0e7c185a4f232bd067ee3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c444t-fab84eede27f36a6ee1f5cd2b33b4017347e5de84ecf0e7c185a4f232bd067ee3 |
| container_end_page | 156 |
| container_issue | |
| container_start_page | 152 |
| container_title | Atherosclerosis |
| container_volume | 268 |
| creator | Indhirajanti, Swasti van Daele, Paul L.A. Bos, Sven Mulder, Monique T. Bot, Ilze Roeters van Lennep, Jeanine E. |
| description | Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prevalence of CVD and cardiovascular risk factors in patients with systemic mastocytosis (SM) and controls.
In 50 patients with SM and 50 age and sex matched controls, the history of CVD and presence of cardiovascular risk factors were assessed. Carotid ultrasound was performed to assess carotid intima-media thickness (C-IMT) and plaques presence.
CVD events were more prevalent in SM patients compared to controls (20% vs. 6%, p = 0.04). The prevalence of C-IMT and carotid plaques was similar between patients with SM and controls. In multivariate analysis, CVD events were significantly associated with SM (OR 7.0 (95% CI 1.3–37.6), p = 0.02) and hypertension (OR 9.5 (95% CI 1.9–48.7), p = 0.01). The prevalence of diabetes, hypertension, obesity and smoking was similar between the two groups. Total cholesterol and LDL-C levels were significantly lower in SM patients than in the control group. (5.1 ± 1.1 vs. 5.9 ± 0.9 mmol/l, p |
| doi_str_mv | 10.1016/j.atherosclerosis.2017.11.030 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1976001881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915017314156</els_id><sourcerecordid>1976001881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-fab84eede27f36a6ee1f5cd2b33b4017347e5de84ecf0e7c185a4f232bd067ee3</originalsourceid><addsrcrecordid>eNqNkLFuFDEQhi1ERI7AKyA3SDS7eLy-ta-gQBEEpEgUSUpkee1ZxSfv7eLxXXRvj08XKKhoZppv5tf_MfYeRAsC-o_b1pVHzDP5dJqRWilAtwCt6MQLtgKjNw0oo16ylRASmg2sxSV7TbQVQigN5hW7lBsptenNiv28O1LBKXo-OSqzP5bTT-6IZh9dQeJPsTxy73KI88GR3yeXOR5wV4gHpCUW5Gl-wsyX5GhyPMUlBp4qkugNuxhdInz7vK_Yw9cv99ffmtsfN9-vP982XilVmtENRiEGlHrsetcjwrj2QQ5dN6jarlMa1wEr40eB2oNZOzXKTg5B9Bqxu2Ifzn-XPP_aIxU7RfKYktvhvCcLG90LAcZART-dUV_tUcbRLjlOLh8tCHsybLf2H8P2ZNgC2Gq43r97jtoPE4a_13-UVuDmDNT-eIiYLfmIO48hZvTFhjn-Z9Rv6tGaWw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1976001881</pqid></control><display><type>article</type><title>Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels</title><source>ScienceDirect Journals</source><creator>Indhirajanti, Swasti ; van Daele, Paul L.A. ; Bos, Sven ; Mulder, Monique T. ; Bot, Ilze ; Roeters van Lennep, Jeanine E.</creator><creatorcontrib>Indhirajanti, Swasti ; van Daele, Paul L.A. ; Bos, Sven ; Mulder, Monique T. ; Bot, Ilze ; Roeters van Lennep, Jeanine E.</creatorcontrib><description>Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prevalence of CVD and cardiovascular risk factors in patients with systemic mastocytosis (SM) and controls.
In 50 patients with SM and 50 age and sex matched controls, the history of CVD and presence of cardiovascular risk factors were assessed. Carotid ultrasound was performed to assess carotid intima-media thickness (C-IMT) and plaques presence.
CVD events were more prevalent in SM patients compared to controls (20% vs. 6%, p = 0.04). The prevalence of C-IMT and carotid plaques was similar between patients with SM and controls. In multivariate analysis, CVD events were significantly associated with SM (OR 7.0 (95% CI 1.3–37.6), p = 0.02) and hypertension (OR 9.5 (95% CI 1.9–48.7), p = 0.01). The prevalence of diabetes, hypertension, obesity and smoking was similar between the two groups. Total cholesterol and LDL-C levels were significantly lower in SM patients than in the control group. (5.1 ± 1.1 vs. 5.9 ± 0.9 mmol/l, p < 0.05 and 2.9 ± 0.8 vs. 3.5 ± 0.7 mmol/l, p < 0.05, respectively).
Despite lower plasma total cholesterol and LDL-C, the prevalence of CVD is higher in patients with SM compared to healthy controls. Beyond the setting of SM, this study can be considered as a proof of concept study, indicating the contribution of mast cells to CVD in humans.
•Systemic mastocytosis patients have more cardiovascular disease compared to controls.•This is despite lower total cholesterol and LDL-cholesterol in SM patients.•Mast cells might contribute to atherosclerotic plaque destabilization.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2017.11.030</identifier><identifier>PMID: 29227868</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aged ; Atherosclerosis ; Biomarkers - blood ; Cardiovascular disease ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - epidemiology ; Carotid Intima-Media Thickness ; Carotid plaques ; Case-Control Studies ; Cholesterol - blood ; Cholesterol, LDL - blood ; Diabetes Mellitus - epidemiology ; Female ; Humans ; Hypertension - epidemiology ; LDL-Cholesterol ; Male ; Mastocytosis, Systemic - blood ; Mastocytosis, Systemic - diagnosis ; Mastocytosis, Systemic - epidemiology ; Middle Aged ; Netherlands - epidemiology ; Obesity - epidemiology ; Pilot Projects ; Plaque, Atherosclerotic ; Prevalence ; Risk Assessment ; Risk Factors ; Smoking - adverse effects ; Smoking - epidemiology ; Systemic mastocytosis</subject><ispartof>Atherosclerosis, 2018-01, Vol.268, p.152-156</ispartof><rights>2018 The Authors</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-fab84eede27f36a6ee1f5cd2b33b4017347e5de84ecf0e7c185a4f232bd067ee3</citedby><cites>FETCH-LOGICAL-c444t-fab84eede27f36a6ee1f5cd2b33b4017347e5de84ecf0e7c185a4f232bd067ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29227868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Indhirajanti, Swasti</creatorcontrib><creatorcontrib>van Daele, Paul L.A.</creatorcontrib><creatorcontrib>Bos, Sven</creatorcontrib><creatorcontrib>Mulder, Monique T.</creatorcontrib><creatorcontrib>Bot, Ilze</creatorcontrib><creatorcontrib>Roeters van Lennep, Jeanine E.</creatorcontrib><title>Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prevalence of CVD and cardiovascular risk factors in patients with systemic mastocytosis (SM) and controls.
In 50 patients with SM and 50 age and sex matched controls, the history of CVD and presence of cardiovascular risk factors were assessed. Carotid ultrasound was performed to assess carotid intima-media thickness (C-IMT) and plaques presence.
CVD events were more prevalent in SM patients compared to controls (20% vs. 6%, p = 0.04). The prevalence of C-IMT and carotid plaques was similar between patients with SM and controls. In multivariate analysis, CVD events were significantly associated with SM (OR 7.0 (95% CI 1.3–37.6), p = 0.02) and hypertension (OR 9.5 (95% CI 1.9–48.7), p = 0.01). The prevalence of diabetes, hypertension, obesity and smoking was similar between the two groups. Total cholesterol and LDL-C levels were significantly lower in SM patients than in the control group. (5.1 ± 1.1 vs. 5.9 ± 0.9 mmol/l, p < 0.05 and 2.9 ± 0.8 vs. 3.5 ± 0.7 mmol/l, p < 0.05, respectively).
Despite lower plasma total cholesterol and LDL-C, the prevalence of CVD is higher in patients with SM compared to healthy controls. Beyond the setting of SM, this study can be considered as a proof of concept study, indicating the contribution of mast cells to CVD in humans.
•Systemic mastocytosis patients have more cardiovascular disease compared to controls.•This is despite lower total cholesterol and LDL-cholesterol in SM patients.•Mast cells might contribute to atherosclerotic plaque destabilization.</description><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Carotid plaques</subject><subject>Case-Control Studies</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>LDL-Cholesterol</subject><subject>Male</subject><subject>Mastocytosis, Systemic - blood</subject><subject>Mastocytosis, Systemic - diagnosis</subject><subject>Mastocytosis, Systemic - epidemiology</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Obesity - epidemiology</subject><subject>Pilot Projects</subject><subject>Plaque, Atherosclerotic</subject><subject>Prevalence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Systemic mastocytosis</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqNkLFuFDEQhi1ERI7AKyA3SDS7eLy-ta-gQBEEpEgUSUpkee1ZxSfv7eLxXXRvj08XKKhoZppv5tf_MfYeRAsC-o_b1pVHzDP5dJqRWilAtwCt6MQLtgKjNw0oo16ylRASmg2sxSV7TbQVQigN5hW7lBsptenNiv28O1LBKXo-OSqzP5bTT-6IZh9dQeJPsTxy73KI88GR3yeXOR5wV4gHpCUW5Gl-wsyX5GhyPMUlBp4qkugNuxhdInz7vK_Yw9cv99ffmtsfN9-vP982XilVmtENRiEGlHrsetcjwrj2QQ5dN6jarlMa1wEr40eB2oNZOzXKTg5B9Bqxu2Ifzn-XPP_aIxU7RfKYktvhvCcLG90LAcZART-dUV_tUcbRLjlOLh8tCHsybLf2H8P2ZNgC2Gq43r97jtoPE4a_13-UVuDmDNT-eIiYLfmIO48hZvTFhjn-Z9Rv6tGaWw</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Indhirajanti, Swasti</creator><creator>van Daele, Paul L.A.</creator><creator>Bos, Sven</creator><creator>Mulder, Monique T.</creator><creator>Bot, Ilze</creator><creator>Roeters van Lennep, Jeanine E.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201801</creationdate><title>Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels</title><author>Indhirajanti, Swasti ; van Daele, Paul L.A. ; Bos, Sven ; Mulder, Monique T. ; Bot, Ilze ; Roeters van Lennep, Jeanine E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-fab84eede27f36a6ee1f5cd2b33b4017347e5de84ecf0e7c185a4f232bd067ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular disease</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Carotid plaques</topic><topic>Case-Control Studies</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>LDL-Cholesterol</topic><topic>Male</topic><topic>Mastocytosis, Systemic - blood</topic><topic>Mastocytosis, Systemic - diagnosis</topic><topic>Mastocytosis, Systemic - epidemiology</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Obesity - epidemiology</topic><topic>Pilot Projects</topic><topic>Plaque, Atherosclerotic</topic><topic>Prevalence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Systemic mastocytosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Indhirajanti, Swasti</creatorcontrib><creatorcontrib>van Daele, Paul L.A.</creatorcontrib><creatorcontrib>Bos, Sven</creatorcontrib><creatorcontrib>Mulder, Monique T.</creatorcontrib><creatorcontrib>Bot, Ilze</creatorcontrib><creatorcontrib>Roeters van Lennep, Jeanine E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Indhirajanti, Swasti</au><au>van Daele, Paul L.A.</au><au>Bos, Sven</au><au>Mulder, Monique T.</au><au>Bot, Ilze</au><au>Roeters van Lennep, Jeanine E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2018-01</date><risdate>2018</risdate><volume>268</volume><spage>152</spage><epage>156</epage><pages>152-156</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prevalence of CVD and cardiovascular risk factors in patients with systemic mastocytosis (SM) and controls.
In 50 patients with SM and 50 age and sex matched controls, the history of CVD and presence of cardiovascular risk factors were assessed. Carotid ultrasound was performed to assess carotid intima-media thickness (C-IMT) and plaques presence.
CVD events were more prevalent in SM patients compared to controls (20% vs. 6%, p = 0.04). The prevalence of C-IMT and carotid plaques was similar between patients with SM and controls. In multivariate analysis, CVD events were significantly associated with SM (OR 7.0 (95% CI 1.3–37.6), p = 0.02) and hypertension (OR 9.5 (95% CI 1.9–48.7), p = 0.01). The prevalence of diabetes, hypertension, obesity and smoking was similar between the two groups. Total cholesterol and LDL-C levels were significantly lower in SM patients than in the control group. (5.1 ± 1.1 vs. 5.9 ± 0.9 mmol/l, p < 0.05 and 2.9 ± 0.8 vs. 3.5 ± 0.7 mmol/l, p < 0.05, respectively).
Despite lower plasma total cholesterol and LDL-C, the prevalence of CVD is higher in patients with SM compared to healthy controls. Beyond the setting of SM, this study can be considered as a proof of concept study, indicating the contribution of mast cells to CVD in humans.
•Systemic mastocytosis patients have more cardiovascular disease compared to controls.•This is despite lower total cholesterol and LDL-cholesterol in SM patients.•Mast cells might contribute to atherosclerotic plaque destabilization.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29227868</pmid><doi>10.1016/j.atherosclerosis.2017.11.030</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9150 |
| ispartof | Atherosclerosis, 2018-01, Vol.268, p.152-156 |
| issn | 0021-9150 1879-1484 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1976001881 |
| source | ScienceDirect Journals |
| subjects | Aged Atherosclerosis Biomarkers - blood Cardiovascular disease Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - epidemiology Carotid Intima-Media Thickness Carotid plaques Case-Control Studies Cholesterol - blood Cholesterol, LDL - blood Diabetes Mellitus - epidemiology Female Humans Hypertension - epidemiology LDL-Cholesterol Male Mastocytosis, Systemic - blood Mastocytosis, Systemic - diagnosis Mastocytosis, Systemic - epidemiology Middle Aged Netherlands - epidemiology Obesity - epidemiology Pilot Projects Plaque, Atherosclerotic Prevalence Risk Assessment Risk Factors Smoking - adverse effects Smoking - epidemiology Systemic mastocytosis |
| title | Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T23%3A20%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Systemic%20mastocytosis%20associates%20with%20cardiovascular%20events%20despite%20lower%20plasma%20lipid%20levels&rft.jtitle=Atherosclerosis&rft.au=Indhirajanti,%20Swasti&rft.date=2018-01&rft.volume=268&rft.spage=152&rft.epage=156&rft.pages=152-156&rft.issn=0021-9150&rft.eissn=1879-1484&rft_id=info:doi/10.1016/j.atherosclerosis.2017.11.030&rft_dat=%3Cproquest_cross%3E1976001881%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c444t-fab84eede27f36a6ee1f5cd2b33b4017347e5de84ecf0e7c185a4f232bd067ee3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1976001881&rft_id=info:pmid/29227868&rfr_iscdi=true |