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Clinical characteristics and outcomes of patients with chronic disseminated candidiasis who need adjuvant corticosteroid therapy
We performed a retrospective study involving 21 patients with chronic disseminate candidiasis (CDC) and 38 patients with candidemia. Neutropenia of >2 weeks' duration was more common in those with CDC (71%) than in those with candidemia (26%, P < .001), and the azole-resistant rate in pat...
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| Published in: | Medical mycology (Oxford) 2018-08, Vol.56 (6), p.782-786 |
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| Main Authors: | , , , , , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c323t-227927f50b45f00f25f279ef766b9356f9017b6fcb70b1f21f31382c829f58aa3 |
| container_end_page | 786 |
| container_issue | 6 |
| container_start_page | 782 |
| container_title | Medical mycology (Oxford) |
| container_volume | 56 |
| creator | Jang, Young-Rock Kim, Min-Chul Kim, Taeeun Chong, Yong Pil Lee, Sang-Oh Choi, Sang-Ho Kim, Yang Soo Woo, Jun Hee Hong, Jung Yong Yoon, Dok Hyun Suh, Cheolwon Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Kim, Sung-Han |
| description | We performed a retrospective study involving 21 patients with chronic disseminate candidiasis (CDC) and 38 patients with candidemia. Neutropenia of >2 weeks' duration was more common in those with CDC (71%) than in those with candidemia (26%, P < .001), and the azole-resistant rate in patients with CDC (5%) was lower than that in those with candidemia (29%, P = .03). Of the 21 patients with CDC, five (24%) needed adjuvant corticosteroid therapy due to persistent debilitating fever (median, 19 days). Rapid defervescence (median, 5 days) occurred after adjuvant corticosteroid therapy. However, there were no significant differences in 90-day mortality between CDC patients with and without corticosteroid therapy. Further prospective data are needed to define the role of steroids in this setting. |
| doi_str_mv | 10.1093/mmy/myx110 |
| format | article |
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Neutropenia of >2 weeks' duration was more common in those with CDC (71%) than in those with candidemia (26%, P < .001), and the azole-resistant rate in patients with CDC (5%) was lower than that in those with candidemia (29%, P = .03). Of the 21 patients with CDC, five (24%) needed adjuvant corticosteroid therapy due to persistent debilitating fever (median, 19 days). Rapid defervescence (median, 5 days) occurred after adjuvant corticosteroid therapy. However, there were no significant differences in 90-day mortality between CDC patients with and without corticosteroid therapy. Further prospective data are needed to define the role of steroids in this setting.</description><identifier>ISSN: 1369-3786</identifier><identifier>EISSN: 1460-2709</identifier><identifier>DOI: 10.1093/mmy/myx110</identifier><identifier>PMID: 29228331</identifier><language>eng</language><publisher>England</publisher><subject>Adjuvants, Immunologic - therapeutic use ; Adrenal Cortex Hormones - therapeutic use ; Adult ; Antifungal Agents - therapeutic use ; Candida - classification ; Candidemia - diagnosis ; Candidemia - drug therapy ; Candidemia - microbiology ; Candidemia - physiopathology ; Candidiasis - diagnosis ; Candidiasis - drug therapy ; Candidiasis - microbiology ; Candidiasis - physiopathology ; Chronic Disease ; Combined Modality Therapy ; Drug Resistance, Fungal ; Female ; Fever - drug therapy ; Humans ; Immune Reconstitution Inflammatory Syndrome - drug therapy ; Immune Reconstitution Inflammatory Syndrome - physiopathology ; Male ; Middle Aged ; Neutropenia - complications ; Opportunistic Infections - diagnosis ; Opportunistic Infections - drug therapy ; Opportunistic Infections - microbiology ; Opportunistic Infections - physiopathology ; Retrospective Studies ; Treatment Outcome</subject><ispartof>Medical mycology (Oxford), 2018-08, Vol.56 (6), p.782-786</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-227927f50b45f00f25f279ef766b9356f9017b6fcb70b1f21f31382c829f58aa3</citedby><cites>FETCH-LOGICAL-c323t-227927f50b45f00f25f279ef766b9356f9017b6fcb70b1f21f31382c829f58aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29228331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Young-Rock</creatorcontrib><creatorcontrib>Kim, Min-Chul</creatorcontrib><creatorcontrib>Kim, Taeeun</creatorcontrib><creatorcontrib>Chong, Yong Pil</creatorcontrib><creatorcontrib>Lee, Sang-Oh</creatorcontrib><creatorcontrib>Choi, Sang-Ho</creatorcontrib><creatorcontrib>Kim, Yang Soo</creatorcontrib><creatorcontrib>Woo, Jun Hee</creatorcontrib><creatorcontrib>Hong, Jung Yong</creatorcontrib><creatorcontrib>Yoon, Dok Hyun</creatorcontrib><creatorcontrib>Suh, Cheolwon</creatorcontrib><creatorcontrib>Lee, Jung-Hee</creatorcontrib><creatorcontrib>Lee, Je-Hwan</creatorcontrib><creatorcontrib>Lee, Kyoo-Hyung</creatorcontrib><creatorcontrib>Kim, Sung-Han</creatorcontrib><title>Clinical characteristics and outcomes of patients with chronic disseminated candidiasis who need adjuvant corticosteroid therapy</title><title>Medical mycology (Oxford)</title><addtitle>Med Mycol</addtitle><description>We performed a retrospective study involving 21 patients with chronic disseminate candidiasis (CDC) and 38 patients with candidemia. Neutropenia of >2 weeks' duration was more common in those with CDC (71%) than in those with candidemia (26%, P < .001), and the azole-resistant rate in patients with CDC (5%) was lower than that in those with candidemia (29%, P = .03). Of the 21 patients with CDC, five (24%) needed adjuvant corticosteroid therapy due to persistent debilitating fever (median, 19 days). Rapid defervescence (median, 5 days) occurred after adjuvant corticosteroid therapy. However, there were no significant differences in 90-day mortality between CDC patients with and without corticosteroid therapy. 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Kim, Min-Chul ; Kim, Taeeun ; Chong, Yong Pil ; Lee, Sang-Oh ; Choi, Sang-Ho ; Kim, Yang Soo ; Woo, Jun Hee ; Hong, Jung Yong ; Yoon, Dok Hyun ; Suh, Cheolwon ; Lee, Jung-Hee ; Lee, Je-Hwan ; Lee, Kyoo-Hyung ; Kim, Sung-Han</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-227927f50b45f00f25f279ef766b9356f9017b6fcb70b1f21f31382c829f58aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Adult</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Candida - classification</topic><topic>Candidemia - diagnosis</topic><topic>Candidemia - drug therapy</topic><topic>Candidemia - microbiology</topic><topic>Candidemia - physiopathology</topic><topic>Candidiasis - diagnosis</topic><topic>Candidiasis - drug therapy</topic><topic>Candidiasis - microbiology</topic><topic>Candidiasis - physiopathology</topic><topic>Chronic Disease</topic><topic>Combined Modality Therapy</topic><topic>Drug Resistance, Fungal</topic><topic>Female</topic><topic>Fever - drug therapy</topic><topic>Humans</topic><topic>Immune Reconstitution Inflammatory Syndrome - drug therapy</topic><topic>Immune Reconstitution Inflammatory Syndrome - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutropenia - complications</topic><topic>Opportunistic Infections - diagnosis</topic><topic>Opportunistic Infections - drug therapy</topic><topic>Opportunistic Infections - microbiology</topic><topic>Opportunistic Infections - physiopathology</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Young-Rock</creatorcontrib><creatorcontrib>Kim, Min-Chul</creatorcontrib><creatorcontrib>Kim, Taeeun</creatorcontrib><creatorcontrib>Chong, Yong Pil</creatorcontrib><creatorcontrib>Lee, Sang-Oh</creatorcontrib><creatorcontrib>Choi, Sang-Ho</creatorcontrib><creatorcontrib>Kim, Yang Soo</creatorcontrib><creatorcontrib>Woo, Jun Hee</creatorcontrib><creatorcontrib>Hong, Jung Yong</creatorcontrib><creatorcontrib>Yoon, Dok Hyun</creatorcontrib><creatorcontrib>Suh, Cheolwon</creatorcontrib><creatorcontrib>Lee, Jung-Hee</creatorcontrib><creatorcontrib>Lee, Je-Hwan</creatorcontrib><creatorcontrib>Lee, Kyoo-Hyung</creatorcontrib><creatorcontrib>Kim, Sung-Han</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical mycology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Young-Rock</au><au>Kim, Min-Chul</au><au>Kim, Taeeun</au><au>Chong, Yong Pil</au><au>Lee, Sang-Oh</au><au>Choi, Sang-Ho</au><au>Kim, Yang Soo</au><au>Woo, Jun Hee</au><au>Hong, Jung Yong</au><au>Yoon, Dok Hyun</au><au>Suh, Cheolwon</au><au>Lee, Jung-Hee</au><au>Lee, Je-Hwan</au><au>Lee, Kyoo-Hyung</au><au>Kim, Sung-Han</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and outcomes of patients with chronic disseminated candidiasis who need adjuvant corticosteroid therapy</atitle><jtitle>Medical mycology (Oxford)</jtitle><addtitle>Med Mycol</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>56</volume><issue>6</issue><spage>782</spage><epage>786</epage><pages>782-786</pages><issn>1369-3786</issn><eissn>1460-2709</eissn><abstract>We performed a retrospective study involving 21 patients with chronic disseminate candidiasis (CDC) and 38 patients with candidemia. 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| identifier | ISSN: 1369-3786 |
| ispartof | Medical mycology (Oxford), 2018-08, Vol.56 (6), p.782-786 |
| issn | 1369-3786 1460-2709 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Adjuvants, Immunologic - therapeutic use Adrenal Cortex Hormones - therapeutic use Adult Antifungal Agents - therapeutic use Candida - classification Candidemia - diagnosis Candidemia - drug therapy Candidemia - microbiology Candidemia - physiopathology Candidiasis - diagnosis Candidiasis - drug therapy Candidiasis - microbiology Candidiasis - physiopathology Chronic Disease Combined Modality Therapy Drug Resistance, Fungal Female Fever - drug therapy Humans Immune Reconstitution Inflammatory Syndrome - drug therapy Immune Reconstitution Inflammatory Syndrome - physiopathology Male Middle Aged Neutropenia - complications Opportunistic Infections - diagnosis Opportunistic Infections - drug therapy Opportunistic Infections - microbiology Opportunistic Infections - physiopathology Retrospective Studies Treatment Outcome |
| title | Clinical characteristics and outcomes of patients with chronic disseminated candidiasis who need adjuvant corticosteroid therapy |
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