Susceptibility of HLA-E01:03 Allele Carriers to Develop Cytomegalovirus Replication After Living-Donor Kidney Transplantation

Cytomegalovirus (CMV) causes serious complications among solid organ transplant recipients. We report the positive correlation between the presence of the HLA-E*01:03 allele in living-donor kidney recipients and CMV reactivation during the first year after transplantation. Thus, HLA-E genotyping may...

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Bibliographic Details
Published in:The Journal of infectious diseases 2018-05, Vol.217 (12), p.1918-1922
Main Authors: Guberina, Hana, da Silva Nardi, Fabiola, Michita, Rafael Tomoya, Dolff, Sebastian, Bienholz, Anja, Heinemann, Falko M, Wilde, Benjamin, Trilling, Mirko, Horn, Peter A, Kribben, Andreas, Witzke, Oliver, Rebmann, Vera
Format: Article
Language:English
Subjects:
Adult
Alleles
Cytomegalovirus - pathogenicity
Cytomegalovirus Infections - genetics
Female
Histocompatibility Antigens Class I - genetics
HLA-E Antigens
Humans
Kidney Transplantation - methods
Living Donors
Male
Middle Aged
Transplant Recipients
Virus Replication - genetics
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Summary:Cytomegalovirus (CMV) causes serious complications among solid organ transplant recipients. We report the positive correlation between the presence of the HLA-E*01:03 allele in living-donor kidney recipients and CMV reactivation during the first year after transplantation. Thus, HLA-E genotyping may help identify CMV replication-prone patients who require individualized patient-based CMV management.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jix638