Polypharmacy, chronic kidney disease, and benign prostatic hyperplasia in patients with chronic obstructive pulmonary disease newly treated with long-acting anticholinergics

•The prevalence of polypharmacy, CKD and, in men, BPH increases with age.•Polypharmacy is highly prevalent across all age in COPD patients initiating a LAAC.•Polypharmacy, CKD, and BPH significantly increase the incidence of AUR.•Physicians should monitor AUR following initiation of a LAAC among COP...

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Bibliographic Details
Published in:Respiratory medicine 2017-11, Vol.132, p.195-202
Main Authors: Savaria, François, Beauchesne, Marie-France, Forget, Amélie, Blais, Lucie
Format: Article
Language:English
Subjects:
Acute urinary retention
Administration, Inhalation
Aged
Anticholinergics
Benign prostatic hyperplasia
Canada - epidemiology
Cholinergic Antagonists - administration & dosage
Cholinergic Antagonists - adverse effects
Chronic kidney disease
Chronic obstructive pulmonary disease
Cohort Studies
Comorbidity
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - adverse effects
Drug-Related Side Effects and Adverse Reactions - diagnosis
Genital diseases
Humans
Hyperplasia
Incidence
Kidney diseases
Long-acting anticholinergics
Lung diseases
Male
Middle Aged
Obstructive lung disease
Polypharmacy
Prevalence
Prostatic Hyperplasia - diagnosis
Prostatic Hyperplasia - drug therapy
Prostatic Hyperplasia - epidemiology
Pulmonary Disease, Chronic Obstructive - drug therapy
Pulmonary Disease, Chronic Obstructive - epidemiology
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - drug therapy
Renal Insufficiency, Chronic - epidemiology
Retrospective Studies
Risk Factors
Urinary Retention - chemically induced
Urinary Retention - diagnosis
Urinary Retention - epidemiology
Urinary Retention - prevention & control
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Description
Summary:•The prevalence of polypharmacy, CKD and, in men, BPH increases with age.•Polypharmacy is highly prevalent across all age in COPD patients initiating a LAAC.•Polypharmacy, CKD, and BPH significantly increase the incidence of AUR.•Physicians should monitor AUR following initiation of a LAAC among COPD patients.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2017.10.023