Inhibitory effects of edible marine algae extracts on degranulation of RBL-2H3 cells and mouse eosinophils

Inhibitory effects on degranulation of rat basophilic leukemia (RBL-2H3) cells and mouse eosinophils by marine algae extracts were examined. More than 50% of the degranulation of RBL-2H3 cells was inhibited by water extracts of Ecklonia cava and Chrysymenia wrightii at a concentration of 100 μg/mL....

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Published in:Fisheries science 2008-10, Vol.74 (5), p.1157-1165
Main Authors: Kimiya, T.(Kochi Univ., Nankoku (Japan)), Ohtani, K, Satoh, S, Abe, Y, Ogita, Y, Kawakita, H, Hamada, H, Konishi, Y, Kubota, S, Tominaga, A
Format: Article
Language:English
Subjects:
Algae
ALGAS MARINAS
ALGUE MARINE
anti‐allergic substances
Biomedical and Life Sciences
Chromatography
Chrysymenia
Codium fragile
degranulation
Deodorants
Ecklonia cava
eosinophils
EXTRACTOS VEGETALES
EXTRAIT D'ORIGINE VEGETALE
Fish & Wildlife Biology & Management
Fisheries management
Food Science
Freshwater & Marine Ecology
GRANULOCITOS
GRANULOCYTE
GRANULOCYTES
HYPERSENSITIVITY
INHIBICION
INHIBITION
LEUCEMIA
LEUCEMIE
LEUKAEMIA
Leukemia
Life Sciences
marine algae
Marine biology
Methanol
MICE
Petalonia
Petalonia binghamiae
PLANT EXTRACTS
Porphyra dentata
RAT
RATA
RATON
RATS
RBL‐2H3
REACCIONES ALERGICAS
REACTION ALLERGIQUE
Rodents
Scytosiphon lomentaria
SEAWEEDS
Silica
SOURIS
Ulva
Undaria pinnatifida
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cited_by cdi_FETCH-LOGICAL-c5385-4a4ce317cfc688a736bcd8e2f9ba289e95d522ba5dd256ebc8c804b69903baea3
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container_issue 5
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container_title Fisheries science
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creator Kimiya, T.(Kochi Univ., Nankoku (Japan))
Ohtani, K
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Kawakita, H
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Konishi, Y
Kubota, S
Tominaga, A
description Inhibitory effects on degranulation of rat basophilic leukemia (RBL-2H3) cells and mouse eosinophils by marine algae extracts were examined. More than 50% of the degranulation of RBL-2H3 cells was inhibited by water extracts of Ecklonia cava and Chrysymenia wrightii at a concentration of 100 μg/mL. More than 50% of the degranulation of RBL-2H3 cells was inhibited by methanol extracts of Petalonia binghamiae, Scytosiphon lomentaria, Undaria pinnatifida, Porphyra dentata, Codium fragile and Ulva japonica at a concentration of 200 μg/mL. Most inhibitory substances in the methanol extracts were partitioned into ethyl acetate and hexane layers. The ethyl acetate-partitioned layer of methanol extract of Petalonia binghamiae had higher inhibitory effects than the hexane-partitioned layer on the degranulation of RBL-2H3 cells. By contrast, the hexanepartitioned layer of the same extract had a higher inhibitory effect than the ethyl acetate-partitioned layer on the degranulation of mouse eosinophils. The ethyl acetate-partitioned layer of methanol extract of Petalonia binghamiae was further separated into eight fractions by silica gel column chromatography. Most inhibited the degranulation of RBL-2H3 cells, but not that of mouse eosinophils significantly. These results suggest methanol extract of Petalonia binghamiae contains materials that inhibit the degranulation of basophils and eosinophils differentially.
doi_str_mv 10.1111/j.1444-2906.2008.01635.x
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More than 50% of the degranulation of RBL-2H3 cells was inhibited by water extracts of Ecklonia cava and Chrysymenia wrightii at a concentration of 100 μg/mL. More than 50% of the degranulation of RBL-2H3 cells was inhibited by methanol extracts of Petalonia binghamiae, Scytosiphon lomentaria, Undaria pinnatifida, Porphyra dentata, Codium fragile and Ulva japonica at a concentration of 200 μg/mL. Most inhibitory substances in the methanol extracts were partitioned into ethyl acetate and hexane layers. The ethyl acetate-partitioned layer of methanol extract of Petalonia binghamiae had higher inhibitory effects than the hexane-partitioned layer on the degranulation of RBL-2H3 cells. By contrast, the hexanepartitioned layer of the same extract had a higher inhibitory effect than the ethyl acetate-partitioned layer on the degranulation of mouse eosinophils. 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The ethyl acetate-partitioned layer of methanol extract of Petalonia binghamiae was further separated into eight fractions by silica gel column chromatography. Most inhibited the degranulation of RBL-2H3 cells, but not that of mouse eosinophils significantly. These results suggest methanol extract of Petalonia binghamiae contains materials that inhibit the degranulation of basophils and eosinophils differentially.</abstract><cop>Tokyo</cop><pub>Springer-Verlag</pub><doi>10.1111/j.1444-2906.2008.01635.x</doi><tpages>9</tpages></addata></record>
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identifier ISSN: 0919-9268
ispartof Fisheries science, 2008-10, Vol.74 (5), p.1157-1165
issn 0919-9268
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language eng
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source ABI/INFORM global; Springer Nature
subjects Algae
ALGAS MARINAS
ALGUE MARINE
anti‐allergic substances
Biomedical and Life Sciences
Chromatography
Chrysymenia
Codium fragile
degranulation
Deodorants
Ecklonia cava
eosinophils
EXTRACTOS VEGETALES
EXTRAIT D'ORIGINE VEGETALE
Fish & Wildlife Biology & Management
Fisheries management
Food Science
Freshwater & Marine Ecology
GRANULOCITOS
GRANULOCYTE
GRANULOCYTES
HYPERSENSITIVITY
INHIBICION
INHIBITION
LEUCEMIA
LEUCEMIE
LEUKAEMIA
Leukemia
Life Sciences
marine algae
Marine biology
Methanol
MICE
Petalonia
Petalonia binghamiae
PLANT EXTRACTS
Porphyra dentata
RAT
RATA
RATON
RATS
RBL‐2H3
REACCIONES ALERGICAS
REACTION ALLERGIQUE
Rodents
Scytosiphon lomentaria
SEAWEEDS
Silica
SOURIS
Ulva
Undaria pinnatifida
title Inhibitory effects of edible marine algae extracts on degranulation of RBL-2H3 cells and mouse eosinophils
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