The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study

• Published in: Breast cancer research and treatment 2008-09, Vol.111 (1), p.139-144
• Main Authors: Frank, Bernd, Rigas, Sushila H., Bermejo, Justo Lorenzo, Wiestler, Miriam, Wagner, Kerstin, Hemminki, Kari, Reed, Malcolm W., Sutter, Christian, Wappenschmidt, Barbara, Balasubramanian, Sabapathy P., Meindl, Alfons, Kiechle, Marion, Bugert, Peter, Schmutzler, Rita K., Bartram, Claus R., Justenhoven, Christina, Ko, Yon-Dschun, Brüning, Thomas, Brauch, Hiltrud, Hamann, Ute, Pharoah, Paul P. D., Dunning, Alison M., Pooley, Karen A., Easton, Douglas F., Cox, Angela, Burwinkel, Barbara
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Base Sequence; Biological and medical sciences; Breast cancer; Breast Neoplasms - genetics; Cancer research; Case-Control Studies; Caspase 8 - genetics; Epidemiology; Female; Genetic Predisposition to Disease; Genotype; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Oncology; Polymorphism, Genetic; Population genetics; Promoter Regions, Genetic - genetics; Racial differences; Risk Factors; Sequence Deletion; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumors; Whites
• ISSN: 0167-6806; 1573-7217
• DOI: 10.1007/s10549-007-9752-z

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93–1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.