Lipid biomarkers for the peroxisomal and lysosomal disorders: their formation, metabolism and measurement

Lipid biomarkers play important roles in the diagnosis of and monitoring of treatment in peroxisomal disorders and lysosomal storage disorders. Today, a variety of lipids, including very long chain fatty acids, glycolipids, bile acids and the oxidation products of cholesterol, have been considered a...

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Bibliographic Details
Published in:Biomarkers in medicine 2018-01, Vol.12 (1), p.83-95
Main Authors: Mashima, Ryuichi, Maekawa, Masamitsu
Format: Article
Language:English
Subjects:
1-hexacosanoyl-2-hydroxy
Bile acids
Biomarkers
Brain
Cholesterol
cholesterol oxidation products
Chromatography
Dehydrogenases
Disease
Enzymes
Fatty acids
Genes
Genetic counseling
globotriaosylceramide
glycero-3-phosphocholine (LPC26:0)
Glycolipids
Lipid metabolism
Lipids
liquid chromatography-tandem mass spectrometry
Lysosomal storage diseases
lysosomal storage disorders
Mass spectrometry
Medical screening
Metabolism
Metabolites
Oxidation
peroxisomal disorders
Proteins
Scientific imaging
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Summary:Lipid biomarkers play important roles in the diagnosis of and monitoring of treatment in peroxisomal disorders and lysosomal storage disorders. Today, a variety of lipids, including very long chain fatty acids, glycolipids, bile acids and the oxidation products of cholesterol, have been considered as biomarkers for these disorders. In this brief review, the authors summarized the recent advances regarding these lipid biomarkers in terms of their formation, metabolism and measurement in these disorders. An understanding of these biomarkers will offer a key to the development of novel diagnoses and help create more effective therapies in the future.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2017-0225