Potential influence of the phthalates on normal liver function and cardiometabolic risk in males

• Published in: Environmental monitoring and assessment 2018-01, Vol.190 (1), p.17-17, Article 17
• Main Authors: Milošević, Nataša, Milić, Nataša, Živanović Bosić, Dragana, Bajkin, Ivana, Perčić, Ivanka, Abenavoli, Ludovico, Medić Stojanoska, Milica
• Format: Article
• Language: English
• Subjects: Additives; Adipose tissue; Adolescent; Adult; Atmospheric Protection/Air Quality Control/Air Pollution; Biomarkers - urine; Body Mass Index; Body size; Body weight; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - urine; Cholesterol; Contaminants; Correlation; Cosmetics; Cross-Sectional Studies; Diethylhexyl Phthalate - analogs & derivatives; Diethylhexyl Phthalate - toxicity; Diethylhexyl Phthalate - urine; Earth and Environmental Science; Ecology; Ecotoxicology; Endocrine Disruptors - toxicity; Endocrine Disruptors - urine; Endocrine system; Environment; Environmental Exposure - analysis; Environmental Management; Environmental monitoring; Environmental science; Fertility; Health risks; High density lipoprotein; Humans; Insulin; Insulin resistance; Lipids; Lipoproteins; Liver; Liver - drug effects; Liver - metabolism; Liver Function Tests; Male; Males; Metabolites; Middle Aged; Monitoring/Environmental Analysis; Obesity; Obesity - metabolism; Obesity - urine; Overweight; Phthalate esters; Phthalates; Phthalic Acids - toxicity; Phthalic Acids - urine; Plasticizers; Respiratory diseases; Respiratory disorders; Risk; Risk analysis; Risk factors; Samples; Serum; Serum levels; Statistical analysis; Statistical methods; Statistical significance; Transaminase; Urine; Weight; Young Adult
• ISSN: 0167-6369; 1573-2959
• DOI: 10.1007/s10661-017-6398-0

Phthalates are ubiquitous environmental contaminants, massively used in industry as plasticizers and additives in cosmetics, which may impair the human endocrine system inducing fertility problems, respiratory diseases, obesity, and neuropsychological disorders. The aim of this study was to examine the influence of the monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) on the liver function and cardiometabolic risk factors in males. In this research, 102 male participants (51 normal weight and 51 overweight/obese) were enrolled and examined for phthalate metabolites exposure in urine samples after 12 h of fasting. MEP was found in 28.43% (29/102) volunteers, while MEHP was detected among 20.59% (21/102) participants. Statistically significant increment in transaminase serum levels was observed in MEP-positive normal weight subgroup. Linear correlation was obtained between MEP concentration in urine samples and triglyceride (TG) serum levels ( r 2  = 0.33; p