Relationship between serum anti‐varicella zoster virus antibody titer and time from onset of herpes zoster

Herpes zoster is an internal reactivation of varicella zoster virus, and its onset depends on immunity against this virus. We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dermatology 2018-02, Vol.45 (2), p.189-193
Main Authors: Ihara, Honoka, Miyachi, Motoko, Imafuku, Shinichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral - blood
Antibodies, Viral - immunology
antibody titer
Antiviral drugs
Chicken pox
Child
Child, Preschool
Complement fixation
Complement Fixation Tests
Female
Herpes zoster
Herpes Zoster - blood
Herpes Zoster - immunology
Herpesvirus 3, Human - immunology
Humans
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M
Immunoglobulins
Infant
Male
Middle Aged
Retrospective Studies
Skin
Time Factors
Varicella
varicella zoster virus
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Herpes zoster is an internal reactivation of varicella zoster virus, and its onset depends on immunity against this virus. We have previously reported that antiviral antibody titers are inversely correlated with patient numbers. In this study, we hypothesized that patients with higher titers may be late visitors to the clinic, whose antibodies were already boosted at presentation because of the time lapse between onset of zoster and measurement of antibodies. We analyzed antibody titers of patients with acute herpes zoster who visited Fukuoka University Hospital from January 2009 to May 2016 (n = 141, 62 males and 79 females). Varicella zoster virus‐specific immunoglobulin G, M and complement fixation tests were positive in 93.9%, 12.0% and 64.2% of the patients, respectively. Immunoglobulin G and complement fixation titers were strongly correlated (Spearman's r = 0.8634, P 
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.14168