Pharmacological interaction of α‐bisabolol and diclofenac on nociception, inflammation, and gastric integrity in rats

Preclinical Research & Development The combination of nonsteroidal anti‐inflammatory drugs (NSAIDs) with herbal products having analgesic and anti‐inflammatory effects may increase their beneficial effects and limit their side effects. In this study, the effects of an interaction between α‐bisab...

Full description

Saved in:
Bibliographic Details
Published in:Drug development research 2018-02, Vol.79 (1), p.29-37
Main Authors: Ortiz, Mario I., Cariño‐Cortés, Raquel, Ponce‐Monter, Héctor A., Castañeda‐Hernández, Gilberto, Chávez‐Piña, Aracely Evangelina
Format: Article
Language:English
Subjects:
diclofenac
gastric damage
inflammation
nociception
α‐bisabolol
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preclinical Research & Development The combination of nonsteroidal anti‐inflammatory drugs (NSAIDs) with herbal products having analgesic and anti‐inflammatory effects may increase their beneficial effects and limit their side effects. In this study, the effects of an interaction between α‐bisabolol and the NSAID, diclofenac on nociception (formalin test), inflammation (paw inflammation produced by carrageenan) and gastric injury in rat was assessed. Diclofenac, α‐bisabolol, or diclofenac–α‐bisabolol combinations produced antinociceptive and anti‐inflammatory effects in rat (p 
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.21418