Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors

The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different...

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Bibliographic Details
Published in:Biomarkers in medicine 2018-01, Vol.12 (1), p.35-44
Main Authors: Abrahao-Machado, Lucas Faria, Antunes, Bruno, Filippi, Renee Zon, Volc, Sahlua, Boldrini, Erica, Menezes, Weder P, Reis, Rui M, de Camargo, Olavo Pires
Format: Article
Language:English
Subjects:
5'-Methylthioadenosine phosphorylase
Adolescent
Adult
Aged
Biomarkers
Biomarkers, Tumor - metabolism
Child
Child, Preschool
Children & youth
Ciências Médicas
Disease
ESFT
Ethics
Ewing sarcoma family of tumors
Ewing's sarcoma
Ewings sarcoma
Female
Genes
Hospitals
Humans
Immunohistochemistry
Lung cancer
Male
Medical prognosis
Medicina Básica
Methylthioadenosine phosphorylase
Middle Aged
MTAP
Multivariate Analysis
Neoplasia
Pathology
Phosphorylase
Polyamines
Prognosis
Purine-Nucleoside Phosphorylase - metabolism
Sarcoma, Ewing - metabolism
Sarcoma, Ewing - mortality
Sarcoma, Ewing - pathology
Science & Technology
Soft tissues
Tissue Array Analysis
Tumors
Young Adult
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Description
Summary:The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival (OS). Loss of MTAP expression was significantly associated with lower OS in both univariate and multivariate analyses. Loss of MTAP expression is an independent negative prognostic biomarker in ESFT.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2017-0152