Mediator complex components are frequent targets for genetic alterations in various types of human cancer

The Mediator co-activator complex is a highly conserved,multisubunit protein complex required for gene transcription by RNA polymerase Ⅱ（RNAPⅡ）in all eukaryotes（Allen and Taatjes,2015）.This complex,which consists of at least 30 polypeptides,can be divided into four structurally distinct sub-modules...

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Bibliographic Details
Published in:Journal of genetics and genomics 2017-12, Vol.44 (12), p.587-591
Main Authors: Deng, Libin, Zhang, Cheng, Miao, Duling, Tang, Xiaoli, Luo, Shiwen, Xin, Hong-Bo, Shi, Huidong
Format: Article
Language:English
Subjects:
Computational Biology
Humans
Mediator Complex - genetics
Neoplasms - genetics
Point Mutation
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Summary:The Mediator co-activator complex is a highly conserved,multisubunit protein complex required for gene transcription by RNA polymerase Ⅱ（RNAPⅡ）in all eukaryotes（Allen and Taatjes,2015）.This complex,which consists of at least 30 polypeptides,can be divided into four structurally distinct sub-modules including the head,middle,tail,and cyclin-dependent kinase 8（CDK8）modules （CKM） （Fig. 1A） （Yin and Wang, 2014; Allen and Taatjes, 2015）.
ISSN:1673-8527
DOI:10.1016/j.jgg.2017.08.006