Clinicopathological significance of Bmi-1 overexpression in esophageal cancer: a meta-analysis

The clinicopathological effects of Bmi-1 expression in esophageal cancer remain widely disputed. Our aim was to clarify this relationship. Available studies were retrieved from diverse databases. Review Manager 5.3 and Stata 12.0 software were used to identify correlations between Bmi-1 expression a...

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Bibliographic Details
Published in:Biomarkers in medicine 2018-01, Vol.12 (1), p.71-81
Main Authors: Liu, Jihong, Liu, Kai, Jiang, Xianli, Wang, Xueli, Chen, Yunzhao, Cui, Xiaobin, Pang, Lijuan, Li, Shugang, Liu, Chunxia, Zou, Hong, Yang, Lan, Zhao, Jin, Qi, Yan, Hu, Jian Ming, Li, Feng
Format: Article
Language:English
Subjects:
biomarker
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Bmi protein
Bmi-1
Cancer
Cell adhesion & migration
Cell cycle
clinicopathological features
Colorectal cancer
distant metastasis
Esophageal cancer
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Esophageal Neoplasms - pathology
Esophagus
Humans
invasion
Lung cancer
Lymph nodes
Lymphatic Metastasis - genetics
Medical prognosis
Meta-analysis
Metastases
Metastasis
Neoplasm Staging
Pancreatic cancer
Patients
Polycomb Repressive Complex 1 - genetics
Polycomb Repressive Complex 1 - metabolism
Software
Stem cells
Studies
tumor differentiation
tumor/node/metastasis stage
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Summary:The clinicopathological effects of Bmi-1 expression in esophageal cancer remain widely disputed. Our aim was to clarify this relationship. Available studies were retrieved from diverse databases. Review Manager 5.3 and Stata 12.0 software were used to identify correlations between Bmi-1 expression and the clinicopathological features of esophageal cancer. From 16 studies, 1523 esophageal cancer patients were analyzed. Meta-analysis demonstrated that Bmi-1 overexpression was associated with differentiation (p = 0.03), tumor/node/metastasis stage (p = 0.02), depth of invasion (p = 0.0006) and lymph node metastasis (p = 0.008). The expression of Bmi-1 is associated with the progression and invasion of esophageal cancer.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2017-0092