Cognitive, motor, behavioural and academic performances of children born preterm: a meta‐analysis and systematic review involving 64 061 children

• Published in: BJOG : an international journal of obstetrics and gynaecology 2018-01, Vol.125 (1), p.16-25
• Main Authors: Allotey, J, Zamora, J, Cheong‐See, F, Kalidindi, M, Arroyo‐Manzano, D, Asztalos, E, Post, JAM, Mol, BW, Moore, D, Birtles, D, Khan, KS, Thangaratinam, S
• Format: Article
• Language: English
• Subjects: Academic achievement; Academic performance; Academic Success; Age; attention deficit hyperactivity disorder; Child; Child Behavior Disorders - etiology; Child development; Child, Preschool; Children; Cognition Disorders - etiology; cognitive; Cognitive ability; Developmental Disabilities - etiology; educational performance; Emotional behavior; Evidence-based medicine; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature - physiology; Meta-analysis; Motor ability; Motor skill; motor skills; Motor Skills Disorders - etiology; Motor task performance; Neurodevelopment; Observational Studies as Topic; Premature birth; preterm; Psychomotor Disorders - etiology; Side effects; Systematic review
• ISSN: 1470-0328; 1471-0528
• DOI: 10.1111/1471-0528.14832

Background Preterm birth may leave the brain vulnerable to dysfunction. Knowledge of future neurodevelopmental delay in children born with various degrees of prematurity is needed to inform practice and policy. Objective To quantify the long‐term cognitive, motor, behavioural and academic performance of children born with different degrees of prematurity compared with term‐born children. Search strategy PubMed and Embase were searched from January 1980 to December 2016 without language restrictions. Selection criteria Observational studies that reported neurodevelopmental outcomes from 2 years of age in children born preterm compared with a term‐born cohort. Data collection and analysis We pooled individual estimates of standardised mean differences (SMD) and odds ratios (OR) with 95% confidence intervals using a random effects model. Main results We included 74 studies (64 061 children). Preterm children had lower cognitive scores for FSIQ (SMD: −0.70; 95% CI: −0.73 to −0.66), PIQ (SMD: −0.67; 95% CI: −0.73 to −0.60) and VIQ (SMD: −0.53; 95% CI: −0.60 to −0.47). Lower scores for preterm children in motor skills, behaviour, reading, mathematics and spelling were observed at primary school age, and this persisted to secondary school age, except for mathematics. Gestational age at birth accounted for 38–48% of the observed IQ variance. ADHD was diagnosed twice as often in preterm children (OR: 1.6; 95% CI: 1.3–1.8), with a differential effect observed according to the severity of prematurity (I2 = 49.4%, P = 0.03). Conclusions Prematurity of any degree affects the cognitive performance of children born preterm. The poor neurodevelopment persists at various ages of follow up. Parents, educators, healthcare professionals and policy makers need to take into account the additional academic, emotional and behavioural needs of these children. Tweetable Adverse effect of preterm birth on a child's neurodevelopment persists up to adulthood. Tweetable Adverse effect of preterm birth on a child's neurodevelopment persists up to adulthood.