Influence of Pesticides on Male Fertility

Several studies have shown a decline in human semen quality and increased risks of male subfertility. This paper provides an overview of the mechanisms of pesticide-induced reproductive toxicity and the effects on male fertility since exposure to pesticides may be one of the causes of these disorder...

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Bibliographic Details
Published in:Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 2007-02, Vol.33 (1), p.13-28
Main Authors: Bretveld, Reini, Brouwers, Marijn, Ebisch, Inge, Roeleveld, Nel
Format: Article
Language:English
Subjects:
Agricultural commodities
Biocompatibility
Biological and medical sciences
Biosynthesis
Central nervous system
Central Nervous System - drug effects
Chemical hazards
Chemicals
Cholesterol
Environmental Exposure - adverse effects
Enzymes
Epidemiology
Ethylene dibromide
Exposure
Fertility
Fertility - drug effects
Fertilization - drug effects
Hormones
Hormones - metabolism
Humans
Hypothalamus
In vivo methods and tests
Infertility
Infertility, Male - chemically induced
Laboratory animals
Male
Male fertility
Medical sciences
Men
Metabolism
Metabolites
Organic farming
Pesticidal properties
Pesticide toxicity
Pesticides
Pesticides - adverse effects
Pesticides - pharmacology
Pesticides, fertilizers and other agrochemicals toxicology
Pregnancy
Proteins
Regulation
Review
Semen
Semen - drug effects
Semen analysis
Sperm
Spermatogenesis
Spermatozoa
Testes
Testosterone
Thyroid
Thyroid Gland - drug effects
Toxicity
Toxicology
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Summary:Several studies have shown a decline in human semen quality and increased risks of male subfertility. This paper provides an overview of the mechanisms of pesticide-induced reproductive toxicity and the effects on male fertility since exposure to pesticides may be one of the causes of these disorders. Pesticides may directly damage spermatozoa, alter Sertoli cell or Leydig cell function, or disrupt the endocrine function in any stage of hormonal regulation (hormone synthesis, release, storage, transport, and clearance; receptor recognition and binding; thyroid function; and the central nervous system). These mechanisms are described with respect to the effects of pesticide exposure in vitro and in vivo. In epidemiologie studies, effects on sperm quality and time to pregnancy are reviewed. Clear effects on male fertility have been demonstrated for some pesticides [eg, dibromochloropropane, ethylene dibromide]. But results from more recent studies are inconsistent, and no uniform conclusion can be drawn about the effects of pesticides on male reproduction.
ISSN:0355-3140
1795-990X
DOI:10.5271/sjweh.1060