High-grade thalamic gliomas: Microsurgical treatment and prognosis analysis

•We reviewed 49 patients underwent microsurgical resection of high-grade thalamic gliomas.•Surgical resection is effective for thalamic gliomas, and short-term efficacy is favorable.•Extent of resection are independent prognostic factors for OS.•A combination of surgery and adjuvant chemotherapy/rad...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2018-03, Vol.49, p.56-61
Main Authors: Wu, Biwu, Tang, Chao, Wang, Yang, Li, Zhiqi, Hu, Shukun, Hua, Wei, Li, Wengang, Huang, Shan, Ma, Junfeng, Zhang, Yi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - surgery
Child
Cohort Studies
Disease-Free Survival
Female
Glioma - diagnostic imaging
Glioma - pathology
Glioma - surgery
Humans
Male
Microsurgery - methods
Microsurgical treatment
Middle Aged
Neoplasm Grading
Prognosis
Retrospective Studies
Thalamic gliomas
Thalamic Nuclei - diagnostic imaging
Thalamic Nuclei - surgery
Young Adult
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Summary:•We reviewed 49 patients underwent microsurgical resection of high-grade thalamic gliomas.•Surgical resection is effective for thalamic gliomas, and short-term efficacy is favorable.•Extent of resection are independent prognostic factors for OS.•A combination of surgery and adjuvant chemotherapy/radiotherapy can prolong the survival time. This retrospective study is aimed to investigate the efficacy of microsurgical treatment for high-grade thalamic gliomas, and to analyze the relevant prognosis. From May 2011 to Aug 2015, 49 patients with thalamic gliomas underwent microsurgical resection, and received chemotherapy and radiotherapy postoperatively. The postoperative symptoms and complications were documented, and the overall survival (OS) and the progression-free survival (PFS) data were collected. The prognostic factors were evaluated by univariate and multivariate analyses. Finally, there was no perioperative death. Twenty cases, 24 cases and 5 cases were achieved subtotal resection (>90%), partial resection (70–90%) and less than partial resection (
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2017.12.008