Loading…

Green synthesis of anisotropic zinc oxide nanoparticles with antibacterial and cytofriendly properties

Zinc oxide nanoparticles (ZnONPs) exhibit abundant biomedical applications. Anisotropic ZnONPs with a defined shape and size were synthesized using Bacillus megaterium (NCIM 2326) cell free extract as a bio-reductant. The study investigated the multidimensional effect of ZnONPs on Helicobacter pylor...

Full description

Saved in:
Bibliographic Details
Published in:Microbial pathogenesis 2018-02, Vol.115, p.57-63
Main Authors: Saravanan, M., Gopinath, V., Chaurasia, Mukesh Kumar, Syed, Asad, Ameen, Fuad, Purushothaman, N.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Zinc oxide nanoparticles (ZnONPs) exhibit abundant biomedical applications. Anisotropic ZnONPs with a defined shape and size were synthesized using Bacillus megaterium (NCIM 2326) cell free extract as a bio-reductant. The study investigated the multidimensional effect of ZnONPs on Helicobacter pylori strains and assessed its biosafety in normal human mesenchymal stem cells (hMSc). The highly stable ZnONPs were produced using B. megaterium and Zinc nitrate as a precursor. The phase of ZnONPs formation and structural characterization were performed by UV- visible (UV-Vis), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Field Emission Scanning electron microscopy (FESEM) analysis. Furthermore, the ZnONPs exhibited higher biocompatibility against human mesenchymal stem cells (hMSC) and proved to be potentially safe in mammalian cells. Corroborating the current investigation, we described the anti-H. Pylori dosage of ZnONPs was safe to hMSC and could efficiently use as nano-antibiotic. [Display omitted] •Development of anisotropic ZnONPs using Bacillus megaterium.•ZnONPs characterized by high throughput analytical techniques UV-Vis, XRD, FESEM and FTIR spectrum.•Significant antibacterial efficacy against Helicobacter pylori was observed for ZnONPs.•Biocompatibility of ZnONPs was established on human mesenchymal stem cells.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2017.12.039