Local recurrences after curative IMRT for HNSCC: Effect of different GTV to high-dose CTV margins

• Published in: Radiotherapy and oncology 2018-01, Vol.126 (1), p.48-55
• Main Authors: Zukauskaite, Ruta, Hansen, Christian R., Grau, Cai, Samsøe, Eva, Johansen, Jørgen, Petersen, Jørgen B.B., Andersen, Elo, Brink, Carsten, Overgaard, Jens, Eriksen, Jesper G.
• Format: Article
• Language: English
• Subjects: Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Dose-Response Relationship, Radiation; Female; GTV to CTV margins; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - radiotherapy; HNSCC; Humans; IMRT; Local control; Local recurrence; Male; Margins; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted - methods; Radiotherapy, Intensity-Modulated - methods; Squamous Cell Carcinoma of Head and Neck
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/j.radonc.2017.11.024

The aim was to analyze position of CT-verified local recurrences (LR) and local control (LC) among three centers that used different GTV to CTV1 margins. In total, 1576 patients completing radical primary IMRT for larynx, pharynx, oral cavity HNSCC in three centers in Denmark between 2006 and 2012 were included. CT-verified LRs were analyzed as possible points of recurrence origin and compared between groups of small (0–2.5 mm), larger (>2.5 mm), and anatomical GTV-CTV1 margins. The recurrence point’s position relative to the GTV and 95% prescription dose was evaluated. Overall local control rate was evaluated using Cox uni- and multi-variate analysis. After a median follow-up of 41 months, 272 patients had local failure. Median GTV-CTV1 margin in Center1, 2 and 3 was 0.0, 3.7 and 9.7 mm, respectively. 51% of local recurrences were inside the GTV. No difference in distribution of LRs in relation to GTV surface (p = 0.4) or the dose to LRs (p = 0.2) was detected between the groups. A difference in LC was found univariate between the centers (p = 0.03), but not in multivariate analysis (p = 0.4). No relation was found between the recurrences’ distributions as function of the margins used at three centers. In multivariate analysis, local control was not influenced by the centers.