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Effect of beta-cypermethrin exposure on embryo implantation in mice

•β-CP decreased the rate of embryo implantation.•β-CP disturbed the balance of serum E2 and P4 on day 5 of gestation.•β-CP increased ERa and PRA protein expression levels in the endometria.•β-CP decreased the expression of HoxA10 protein in the endometria. The aim of this study was to investigate th...

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Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2018-03, Vol.76, p.1-11
Main Authors: Zhou, Yong-jiang, Wang, Ji-hong, Wang, Li-qing, Xiao, Sha, Wang, Xiao-dan, Yan, Hua-ling, Li, Cheng-feng, Zhu, Hui-quan
Format: Article
Language:English
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Summary:•β-CP decreased the rate of embryo implantation.•β-CP disturbed the balance of serum E2 and P4 on day 5 of gestation.•β-CP increased ERa and PRA protein expression levels in the endometria.•β-CP decreased the expression of HoxA10 protein in the endometria. The aim of this study was to investigate the effect of β-CP on embryo implantation in mice. Forty female mice were randomly assigned to four groups of 10 mice each: one control group and three β-CP treated groups. The control group was administered corn oil only, while the three β-CP-treated groups were given corn oil containing 5, 10, and 20 mg/kg bw d β-CP for 3 months through intragastric administration. The results indicated that the administration of β-CP decreased the rate of embryo implantation (all p 
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2017.12.001