One-pot biosynthesis of silver nanoparticles using Iboza Riparia and Ilex Mitis for cytotoxicity on human embryonic kidney cells

Plant extracts continue gaining significant prominence in green synthesis of silver nanoparticles (AgNPs), due to their potential applications in nano-medicine and material engineering. This work reports on green synthesis of silver nanoparticles (AgNPs) from aqueous extracts of Iboza Riparia leaf a...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 2018-01, Vol.178, p.560-567
Main Authors: Sabela, Myalowenkosi I., Makhanya, Talent, Kanchi, Suvardhan, Shahbaaz, Mohd, Idress, Danish, Bisetty, Krishna
Format: Article
Language:English
Subjects:
Antioxidant activity
Antioxidants
Bark
Biosynthesis
Chemical properties
Cytotoxicity
Diterpenes
Flowers & plants
Ilex mitis
Kidneys
MTT assay
Nanoparticles
Plant cells
Plant extracts
Saponins
Silver
Silver nanoparticles
Tetradenia riparia
Toxicity
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Summary:Plant extracts continue gaining significant prominence in green synthesis of silver nanoparticles (AgNPs), due to their potential applications in nano-medicine and material engineering. This work reports on green synthesis of silver nanoparticles (AgNPs) from aqueous extracts of Iboza Riparia leaf and Ilex Mitis root bark with diterpenes (DTPs) and saponins (SPNs) as major components. After TEM, DLS, TGA/DSC, ATR, XRD and UV–Vis characterization, the relevant cytotoxicity studies were conducted with the MTT assay on human embryonic kidney cells (HEK293T) followed by antioxidant activity with ABTS. Overall, the AgNPs-DTPs (156nm) were found to be less toxic with 49.7% cell viability, while AgNPs-SPNs (50nm) and AgNPs-PVA (44nm) had cell viability of 40.8 and 28.0% respectively at 400μM. Based on the cytotoxicity and antioxidant activity, it is fair to report that these plant extracts have potential reducing and capping agents as they retain chemical properties on the surface of the nanoparticles. [Display omitted] •First report on biosynthesis of AgNPs with Iboza Riparia and Ilex Mitis extracts.•Antioxidant activity is in the order of AgNPs-DTPs>AgNPs-SPNs.•AgNPs-DTPs were found to be less toxic with 49.7% cell viability.•Scavenging efficiency of AgNPs-DTPs was 96.62% at 400μM.
ISSN:1011-1344
1873-2682
DOI:10.1016/j.jphotobiol.2017.12.010