Safety of tirofiban in patients with acute cerebral infarct receiving endovascular therapy

To investigate the effect of tirofiban on hemorrhagic transformation and neurological outcome in patients with acute cerebral infarct treated with endovascular therapy. One hundred and fifteen patients with acute cerebral infarct who received endovascular stent mechanical thrombectomy in the Second...

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Bibliographic Details
Published in:Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2017-07, Vol.46 (4), p.397-404
Main Authors: Feng, Xuewen, Chen, Zhicai, Zhong, Genlong, Lou, Min
Format: Article
Language:Chinese
Subjects:
Brain Ischemia - therapy
Endovascular Procedures
Humans
Tirofiban - standards
Tirofiban - therapeutic use
Treatment Outcome
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Summary:To investigate the effect of tirofiban on hemorrhagic transformation and neurological outcome in patients with acute cerebral infarct treated with endovascular therapy. One hundred and fifteen patients with acute cerebral infarct who received endovascular stent mechanical thrombectomy in the Second Affiliated Hospital, Zhejiang University School of Medicine during October 2013 and April 2017 were included in the study. Among 115 patients, 30 received tirofiban treatment. Hemorrhagic transformation and neurological outcomes were assessed using the ECASS â…ˇ criteria and modified Rankin scale (mRS), respectively. Unfavorable outcome was defined as mRS>2. Binary logistic regression model was used to analyze the independent predictors of hemorrhagic transformation and neurological outcome. Binary logistic regression analysis showed that tirofiban treatment did not increase the risk of hemorrhagic transformation ( =0.437, 95% :0.168-1.132, >0.05); baseline NIHSS ( =1.136, 95% :1.014-1.273,
ISSN:1008-9292