Variations in the mosquito larvicidal activities of toxins from Bacillus thuringiensis ssp. israelensis

Comparing activities of purified toxins from Bacillus thuringiensis ssp. israelensis against larvae of seven mosquito species (vectors of tropical diseases) that belong to three genera, gleaned from the literature, disclosed highly significant variations in the levels of LC₅₀ as well as in the hiera...

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Bibliographic Details
Published in:Environmental microbiology 2008-09, Vol.10 (9), p.2191-2199
Main Authors: Otieno-Ayayo, Zachariah Ngalo, Zaritsky, Arieh, Wirth, Margaret C, Manasherob, Robert, Khasdan, Vadim, Cahan, Rivka, Ben-Dov, Eitan
Format: Article
Language:English
Subjects:
Animals
Bacillus thuringiensis
Bacillus thuringiensis - chemistry
Bacillus thuringiensis - genetics
Bacterial Proteins - genetics
Bacterial Proteins - pharmacology
Culicidae
Culicidae - drug effects
Culicidae - microbiology
Endotoxins - genetics
Endotoxins - pharmacology
Escherichia coli
Escherichia coli - genetics
Gene Expression
Hemolysin Proteins - genetics
Hemolysin Proteins - pharmacology
Larva - drug effects
Larva - microbiology
Lethal Dose 50
Organisms, Genetically Modified
Pest Control, Biological
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Summary:Comparing activities of purified toxins from Bacillus thuringiensis ssp. israelensis against larvae of seven mosquito species (vectors of tropical diseases) that belong to three genera, gleaned from the literature, disclosed highly significant variations in the levels of LC₅₀ as well as in the hierarchy of susceptibilities. Similar toxicity comparisons were performed between nine transgenic Gram-negative species, four of which are cyanobacterial, expressing various combinations of cry genes, cyt1Aa and p20, against larvae of four mosquito species as potential agents for biological control. Reasons for inconsistencies are listed and discussed. Standard conditions for toxin isolation and presentation to larvae are sought. A set of lyophilized powders prepared identically from six Escherichia coli clones expressing combinations of four genes displayed toxicities against larvae of three mosquito species, with levels that differed between them but with identical hierarchy.
ISSN:1462-2912
1462-2920
DOI:10.1111/j.1462-2920.2008.01696.x