Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas

Pancreatic ductal adenocarcinoma is one of the most debilitating malignancies in humans. Currently, radiation and chemotherapy are ineffective, with median survival times after treatment of

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Bibliographic Details
Published in:Carcinogenesis (New York) 2006-12, Vol.27 (12), p.2497-2510
Main Authors: Ueda, Shinobu, Fukamachi, Katsumi, Matsuoka, Yoichiro, Takasuka, Nobuo, Takeshita, Fumitaka, Naito, Akihiro, Iigo, Masaaki, Alexander, David B., Moore, Malcolm A., Saito, Izumu, Ochiya, Takahiro, Tsuda, Hiroyuki
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenovirus
Animals
Animals, Genetically Modified
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinoma, Pancreatic Ductal - genetics
Carcinoma, Pancreatic Ductal - pathology
Disease Models, Animal
DNA Primers
Gastroenterology. Liver. Pancreas. Abdomen
Genes, ras
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Mutation
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - pathology
Rats
Tumors
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Description
Summary:Pancreatic ductal adenocarcinoma is one of the most debilitating malignancies in humans. Currently, radiation and chemotherapy are ineffective, with median survival times after treatment of
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/bgl090