Nickel Phosphite/Phosphine-Catalyzed C–S Cross-Coupling of Aryl Chlorides and Thiols

A method for the coupling of aryl chlorides and thiophenols using an air-stable nickel(0) catalyst is described. This thioetherification procedure can be effectively applied to a range of electronically diverse aryl/heteroaryl chlorides without more expensive metal catalysts such as palladium, iridi...

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Bibliographic Details
Published in:Organic letters 2018-01, Vol.20 (1), p.208-211
Main Authors: Jones, Kieran D, Power, Dennis J, Bierer, Donald, Gericke, Kersten M, Stewart, Scott G
Format: Article
Language:English
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Summary:A method for the coupling of aryl chlorides and thiophenols using an air-stable nickel(0) catalyst is described. This thioetherification procedure can be effectively applied to a range of electronically diverse aryl/heteroaryl chlorides without more expensive metal catalysts such as palladium, iridium, or ruthenium. This investigation also illustrates both, a variety of thiol coupling partners and, in certain cases, the use of Cs2CO3.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b03560