Serotonergic and cholinergic modulation of functional brain connectivity: A comparison between young and older adults

Aging is accompanied by changes in neurotransmission. To advance our understanding of how aging modifies specific neural circuitries, we examined serotonergic and cholinergic stimulation with resting state functional magnetic resonance imaging (RS-fMRI) in young and older adults. The instant respons...

Full description

Saved in:
Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2018-04, Vol.169, p.312-322
Main Authors: Klaassens, Bernadet L., van Gerven, Joop M.A., Klaassen, Erica S., van der Grond, Jeroen, Rombouts, Serge A.R.B.
Format: Article
Language:English
Subjects:
Acetylcholine
Acetylcholinesterase
Adolescent
Adult
Adults
Age
Aged
Aging
Aging - drug effects
Alcohol
Alzheimer's disease
Body mass index
Brain connectivity
Brain mapping
Caffeine
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - drug effects
Cerebrospinal fluid
Cholinesterase Inhibitors - pharmacokinetics
Cholinesterase Inhibitors - pharmacology
Citalopram
Citalopram - pharmacology
Cognitive ability
Connectome - methods
Cross-Over Studies
Double-Blind Method
Double-blind studies
Drug dosages
Female
Functional magnetic resonance imaging
Galantamine
Galantamine - pharmacology
Geriatrics
Heart rate
Humans
Learning
Magnetic Resonance Imaging
Male
Medical imaging
Medical screening
Memory
Middle Aged
Multivariate analysis
Nerve Net - drug effects
Neural networks
Neuroimaging
Neurotransmission
NMR
Nuclear magnetic resonance
Older people
Resting state network
Sensorimotor system
Serotonin
Serotonin uptake inhibitors
Serotonin Uptake Inhibitors - pharmacokinetics
Serotonin Uptake Inhibitors - pharmacology
Substantia alba
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aging is accompanied by changes in neurotransmission. To advance our understanding of how aging modifies specific neural circuitries, we examined serotonergic and cholinergic stimulation with resting state functional magnetic resonance imaging (RS-fMRI) in young and older adults. The instant response to the selective serotonin reuptake inhibitor citalopram (30 mg) and the acetylcholinesterase inhibitor galantamine (8 mg) was measured in 12 young and 17 older volunteers during a randomized, double blind, placebo-controlled, crossover study. A powerful dataset consisting of 522 RS-fMRI scans was obtained by acquiring multiple scans per subject before and after drug administration. Group × treatment interaction effects on voxelwise connectivity with ten functional networks were investigated (p 
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2017.12.035