Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis

There are numerous extra- and intra-cellular processes involved in the production of reactive oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules such as proteins, nucleic acid and lipids. ROS act as an intracellular signaling component and is associated with various...

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Published in:Chemico-biological interactions 2018-02, Vol.281, p.121-136
Main Authors: Phull, Abdul-Rehman, Nasir, Bakht, Haq, Ihsan ul, Kim, Song Ja
Format: Article
Language:English
Subjects:
Antioxidants
Cellular signaling
Oxidative stress
Rheumatoid arthritis
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description There are numerous extra- and intra-cellular processes involved in the production of reactive oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules such as proteins, nucleic acid and lipids. ROS act as an intracellular signaling component and is associated with various inflammatory responses, chronic arthropathies, including rheumatoid arthritis (RA). It is well documented that ROS can activate different signaling pathways having a vital importance in the patho-physiology of RA. Hence, understanding of the molecular pathways and their interaction might be advantageous in the development of novel therapeutic approaches for RA.
doi_str_mv 10.1016/j.cbi.2017.12.024
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subjects Antioxidants
Cellular signaling
Oxidative stress
Rheumatoid arthritis
title Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis
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