Quantitative analysis of hydrogen peroxide with special emphasis on biosensors

Determination of hydrogen peroxide (H 2 O 2 ) has become essential in pharmaceutical, biological, clinical and environmental studies. The conventional detection methods of H 2 O 2 such as colourimetry, titration, chromatography, spectrophotometry, fluorimetry, chemiluminescence have limited success,...

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Bibliographic Details
Published in:Bioprocess and biosystems engineering 2018-03, Vol.41 (3), p.313-329
Main Authors: Pundir, Chandra S., Deswal, Ritu, Narwal, Vinay
Format: Article
Language:English
Subjects:
Bioengineering
Biosensors
Biotechnology
Chemiluminescence
Chemistry
Chemistry and Materials Science
Critical Review
Environmental Engineering/Biotechnology
Environmental studies
Fluorimetry
Food Science
Hemoglobin
Hydrogen peroxide
Industrial and Production Engineering
Industrial Chemistry/Chemical Engineering
Nanomaterials
Nanoparticles
Nanotechnology
Parameter sensitivity
Quantitative analysis
Reliability analysis
Reproducibility
Selectivity
Sensitivity analysis
Spectrophotometry
Titration
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Summary:Determination of hydrogen peroxide (H 2 O 2 ) has become essential in pharmaceutical, biological, clinical and environmental studies. The conventional detection methods of H 2 O 2 such as colourimetry, titration, chromatography, spectrophotometry, fluorimetry, chemiluminescence have limited success, due to their poor selectivity and sensitivity, long analysis time and lack of long-term reliability and reproducibility. The biosensors overcome these limitations because of their simplicity, rapidity, selectivity and high sensitivity. This review describes the principle, analytic parameters, merits and demerits of various methods of H 2 O 2 determination with special emphasis on biosensors. The classification of biosensors based on various materials/nanomaterials and electrodes have been described in detail. The recent advances in vivo sensing and bio-sensing of H 2 O 2 by hemoglobin nanoparticles are also presented. The significant challenges and future perspective for highly selective H 2 O 2 detection are discussed.
ISSN:1615-7591
1615-7605
DOI:10.1007/s00449-017-1878-8