Research advances in neurological infections in 2017

More routine application of molecular methods, including next generation sequencing, to CSF and brain tissue might contribute to a decrease in the number of cases with unknown causes in the future. A randomised clinical trial5 of Vietnamese patients with tuberculous meningitis, whose treatment inclu...

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Bibliographic Details
Published in:Lancet neurology 2018-01, Vol.17 (1), p.18-19
Main Author: Marra, Christina M
Format: Article
Language:English
Subjects:
Antibodies
Arachnids
Borrelia burgdorferi
Brain research
Cerebrospinal fluid
Dexamethasone
Encephalitis
Gene polymorphism
Herpes viruses
Hydrolase
Infections
Lyme disease
Meningitis
Next-generation sequencing
Polymorphism
Single-nucleotide polymorphism
Tuberculosis
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Summary:More routine application of molecular methods, including next generation sequencing, to CSF and brain tissue might contribute to a decrease in the number of cases with unknown causes in the future. A randomised clinical trial5 of Vietnamese patients with tuberculous meningitis, whose treatment included dexamethasone, examined the effect of the single-nucleotide polymorphism rs17525495 in the promoter region of the leukotriene A4 hydrolase gene (LTA4H). The research group showed that, among 439 individuals, those with the TT genotype were more likely to survive than those with the CC genotype (hazard ratio 3·5, 95% CI 1·1–11·4).
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(17)30409-X