Antibodies as treatment option in older adults

Monoclonal antibodies are already used for many different clinical indications. Besides oncology and rheumatology, denosumab is the only antibody that is currently prescribed in older adults with osteoporosis; however, apart from osteoporosis there might be more possible indications for the use of a...

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Bibliographic Details
Published in:Zeitschrift für Gerontologie und Geriatrie 2018-02, Vol.51 (2), p.152-156
Main Authors: Gosch, M, Wicklein, S
Format: Article
Language:ger
Subjects:
Aged
Aged, 80 and over
Aging - drug effects
Antibodies, Monoclonal - therapeutic use
Cardiovascular Diseases - drug therapy
Chronic Disease - drug therapy
Dementia - drug therapy
Denosumab - therapeutic use
Germany
Humans
Infection - drug therapy
Osteoporosis - drug therapy
Sarcopenia - drug therapy
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Summary:Monoclonal antibodies are already used for many different clinical indications. Besides oncology and rheumatology, denosumab is the only antibody that is currently prescribed in older adults with osteoporosis; however, apart from osteoporosis there might be more possible indications for the use of antibodies in chronic diseases and geriatric syndromes. Particularly, with respect to sarcopenia the transition to "doping for older adults" seems to be fluent. The present review provides an overview on the newest developments and prospective options.
ISSN:1435-1269
DOI:10.1007/s00391-017-1352-x