Association of XRCC4 Codon 247 Polymorphism with Oral Cancer Susceptibility in Taiwan

Background: The DNA repair gene XRCC4, an important caretaker of overall genome stability, is thought to play a major role in the development of human carcinogenesis. However, the association of the polymorphic variants of XRCC4 with oral cancer susceptibility has never been reported. Materials and...

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Published in:Anticancer research 2008-05, Vol.28 (3A), p.1687-1691
Main Authors: TSENG, Hsien-Chang, TSAI, Ming-Hsui, CHIU, Chang-Fang, WANG, Chung-Hsing, CHANG, Nai-Wen, HUANG, Chih-Yang, TSAI, Chia-Wen, LIANG, Shiu-Yun, WANG, Cheng-Li, BAU, Da-Tian
Format: Article
Language:English
Subjects:
Alcohol Drinking - genetics
Alleles
Biological and medical sciences
Case-Control Studies
Codon
DNA-Binding Proteins - genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Introns
Male
Medical sciences
Mouth Neoplasms - genetics
Otorhinolaryngology. Stomatology
Polymorphism, Genetic
Smoking - genetics
Taiwan
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background: The DNA repair gene XRCC4, an important caretaker of overall genome stability, is thought to play a major role in the development of human carcinogenesis. However, the association of the polymorphic variants of XRCC4 with oral cancer susceptibility has never been reported. Materials and Methods: In this hospital-based case-control study, the association of XRCC4 codon 247 (rs3734091), G-1394T (rs6869366), intron 7 (rs28360317) and intron 7 (rs1805377) polymorphisms with oral cancer risk in a Central Taiwanese population was investigated. In total, 318 patients with oral cancer and 318 age- and gender-matched healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped. Results: A significantly different distribution was found in the frequency of the XRCC4 codon 247 genotype, but not the XRCC4 G-1394T or intron 7 genotypes, between the oral cancer and control groups. A/C heterozygosity at XRCC4 codon 247 conferred a significant (2.04-fold) increased risk of oral cancer. As for XRCC4 G-1394T and intron 7 polymorphisms, there was no difference in distribution between the oral cancer and control groups. Gene-environment interactions with smoking, but not with betel quid chewing or alcohol consumption, were significant for XRCC4 codon 247 polymorphism. The XRCC4 codon 247 A/C genotype in association with smoking conferred an increased risk of 3.44 (95% confidence interval = 1.24-9.60) for oral cancer. Conclusion: Our results provide the first evidence that the heterozygous A allele of the XRCC4 codon 247 may be associated with the development of oral cancer and may be a novel useful marker for primary prevention and anticancer intervention.
ISSN:0250-7005
1791-7530