Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers

Drug delivery systems that target the pilosebaceous unit (PSU) selectively could improve the clinical management of diseases that originate in the hair follicle. The aims of this study were (i) to prepare polymeric micelles using d-α-tocopheryl polyethylene glycol succinate diblock copolymer that in...

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Bibliographic Details
Published in:Nanoscale 2018-01, Vol.10 (3), p.1099-1110
Main Authors: Kandekar, Somnath G, Del Río-Sancho, Sergio, Lapteva, Maria, Kalia, Yogeshvar N
Format: Article
Language:English
Subjects:
Acne
Adapalene - administration & dosage
Animals
Drug Delivery Systems
Drug dosages
Formulations
Gels
Hair
Hair Follicle - drug effects
Humans
Micelles
Nanoparticles
Polyethylene glycol
Polymers
Scanning microscopy
Skin
Skin Absorption
Skin Cream
Swine
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Summary:Drug delivery systems that target the pilosebaceous unit (PSU) selectively could improve the clinical management of diseases that originate in the hair follicle. The aims of this study were (i) to prepare polymeric micelles using d-α-tocopheryl polyethylene glycol succinate diblock copolymer that incorporated adapalene (ADA), a retinoid indicated for Acne vulgaris, and (ii) to investigate the feasibility of delivering ADA preferentially to the PSU under finite dose conditions - thereby better approximating actual conditions of use by patients. Incorporation of ADA into spherical micelles (d
ISSN:2040-3364
2040-3372
DOI:10.1039/c7nr07706h