Anal canal squamous cell cancer: are surgical alternatives to chemoradiation just as effective?

Purpose The purpose of this paper is to study long-term oncologic outcomes after different treatment strategies for anal canal cancer (SCAC). Methods Patients with SCAC (2004–2013) were identified from Surveillance, Epidemiology, and End Results (SEER) database. Patients undergoing radiation (RT) we...

Full description

Saved in:
Bibliographic Details
Published in:International journal of colorectal disease 2018-02, Vol.33 (2), p.181-187
Main Authors: Suradkar, Kunal, Pappou, Emmanouil E., Lee-Kong, Steven A., Feingold, Daniel L., Kiran, Ravi P.
Format: Article
Language:English
Subjects:
Cancer
Chemoradiotherapy
Drug therapy
Epidemiology
Gastroenterology
Hepatology
Internal Medicine
Medicine
Medicine & Public Health
Oncology, Experimental
Original Article
Proctology
Radiation
Radiotherapy
Squamous cell carcinoma
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The purpose of this paper is to study long-term oncologic outcomes after different treatment strategies for anal canal cancer (SCAC). Methods Patients with SCAC (2004–2013) were identified from Surveillance, Epidemiology, and End Results (SEER) database. Patients undergoing radiation (RT) were compared to those undergoing local excision (LE), abdominoperineal resection (APR), and abdominoperineal resection after radiation (RT + APR). Overall survival (OS) and cancer-specific survival (CSS) data were evaluated using Kaplan-Meier and Cox regression. Results Two thousand seven hundred and seventy-two (83.8%) patients underwent RT, 382 (11.6%) LE, 77 (2.3%) APR, 76 (2.3%) RT + APR. Median age for the four groups was 60, 57, 64, and 56 years and 32, 49.7, 53.2, and 39.5% were male, respectively, while median tumor size was 4.4, 2.6, 5.3, and 5.5 cm, respectively. Five-year OS of RT, LE, APR, and RT + APR groups was 63.7, 79.6, 25.8, and 41.8% while CSS was 79.6, 92.5, 75.6, and 58.8%, respectively, ( p  
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-017-2938-x