Size-Dependent Inertial Focusing Position Shift and Particle Separations in Triangular Microchannels

A recent study of inertial microfluidics within nonrectangular cross-section channels showed that the inertial focusing positions changes with cross-sectional shapes; therefore, the cross-sectional shape can be a useful control parameter for microfluidic particle manipulations. Here, we conducted de...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2018-02, Vol.90 (3), p.1827-1835
Main Authors: Kim, Jeong-ah, Lee, Je-Ryung, Je, Tae-Jin, Jeon, Eun-chae, Lee, Wonhee
Format: Article
Language:English
Subjects:
Blood
Blood cells
Cells
Channels
Chemistry
Cross-sections
Flow velocity
Fluid dynamics
Fluid flow
Fluids
Inertial coordinates
Microchannels
Microfluidics
Optimization
Particle size
Reynolds number
Separation
Size
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Summary:A recent study of inertial microfluidics within nonrectangular cross-section channels showed that the inertial focusing positions changes with cross-sectional shapes; therefore, the cross-sectional shape can be a useful control parameter for microfluidic particle manipulations. Here, we conducted detail investigation on unique focusing position shift phenomena, which occurs strongly in channels with the cross-sectional shape of the isosceles right triangle. The top focusing positions shift along the channel walls to the direction away from the apex with increasing Reynolds number and decreasing particle size. A larger particle with its center further away from the side walls experiences shear gradient lift toward the apex, which leads to an opposite result with changes of Reynolds and particle size. The focusing position shift and the subsequent stabilization of corner focusing lead to changes in the number of focusing positions, which enables a novel method for microparticle separations with high efficiency (>95%) and resolution (
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.7b03851