Branched antimicrobial peptides

Branched peptides E(RLAR) sub(2), E[E(RLAR) sub(2)] sub(2), and E(KLAR) sub(2), E[E(KLAR) sub(2)] sub(2) were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2007-11, Vol.33 (6), p.544-548
Main Authors: Khrushchev, A. Yu, Kashparov, I. A., Klimenko, L. V., Mitin, Yu. V.
Format: Article
Language:English
Subjects:
Escherichia coli
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Summary:Branched peptides E(RLAR) sub(2), E[E(RLAR) sub(2)] sub(2), and E(KLAR) sub(2), E[E(KLAR) sub(2)] sub(2) were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase in branching, achieving 12 mu M for Escherichia coli cells, which is comparable to antimicrobial activities of temporin, magainin, and dermaseptin. The branched peptides were found not to act on human erythrocytes.
ISSN:1068-1620
1573-9163
1608-330X
DOI:10.1134/S1068162007060027