Polymorphism of detoxification genes and cell resistance to mutagens in patients with Ehlers-Danlos syndrome

Study of polymorphism in 3 genes of the glutathione S-transferase family (GSTM1, GSTT1, and GSTP1) in children with Ehlers-Danlos syndrome whose cells were defective in repair of gamma-induced DNA damages revealed accumulation of GSTM1(+) genotypes compared to children of the control group. Generati...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2007-11, Vol.144 (5), p.717-721
Main Authors: Kuz'mina, N S, Shipaeva, E V, Semyachkina, A N, Vasil'eva, I M, Kovalenko, L P, Durnev, A D, Zasukhina, G D
Format: Article
Language:English
Subjects:
Adolescent
Cadmium Chloride - pharmacology
Child
DNA Damage
Drug Resistance
Ehlers-Danlos Syndrome - blood
Ehlers-Danlos Syndrome - genetics
Female
Gamma Rays
Gene Frequency
Genetic Predisposition to Disease - genetics
Genotype
Glutathione Transferase - genetics
Humans
Lymphocytes - drug effects
Lymphocytes - metabolism
Lymphocytes - radiation effects
Male
Mutagens - pharmacology
Polymorphism, Genetic
Reactive Oxygen Species - metabolism
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Summary:Study of polymorphism in 3 genes of the glutathione S-transferase family (GSTM1, GSTT1, and GSTP1) in children with Ehlers-Danlos syndrome whose cells were defective in repair of gamma-induced DNA damages revealed accumulation of GSTM1(+) genotypes compared to children of the control group. Generation of reactive oxygen species by neutrophils from patients with this syndrome was higher than in healthy donors. Our results indicate that glutathione S-transferase genes are involved in the resistance to mutagenic agents and demonstrate medical and genetic peculiarities of patients with Ehlers-Danlos syndrome.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0414-2