Protein interaction networks from yeast to human

Protein interaction networks summarize large amounts of protein–protein interaction data, both from individual, small-scale experiments and from automated high-throughput screens. The past year has seen a flood of new experimental data, especially on metazoans, as well as an increasing number of ana...

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Bibliographic Details
Published in:Current opinion in structural biology 2004-06, Vol.14 (3), p.292-299
Main Authors: Bork, Peer, Jensen, Lars J, von Mering, Christian, Ramani, Arun K, Lee, Insuk, Marcotte, Edward M
Format: Article
Language:English
Subjects:
Metazoa
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Summary:Protein interaction networks summarize large amounts of protein–protein interaction data, both from individual, small-scale experiments and from automated high-throughput screens. The past year has seen a flood of new experimental data, especially on metazoans, as well as an increasing number of analyses designed to reveal aspects of network topology, modularity and evolution. As only minimal progress has been made in mapping the human proteome using high-throughput screens, the transfer of interaction information within and across species has become increasingly important. With more and more heterogeneous raw data becoming available, proper data integration and quality control have become essential for reliable protein network reconstruction, and will be especially important for reconstructing the human protein interaction network.
ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2004.05.003