Limiting inflammatory responses during activation of innate immunity

The idea of the importance of mounting an inflammatory response for effective immunity is supported by a multiplicity of experimental data. It is also well understood that resolution of inflammation is essential for maintaining the balance between health and disease. When the normal regulatory mecha...

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Bibliographic Details
Published in:Nature Immunology 2005-12, Vol.6 (12), p.1198-1205
Main Authors: Han, Jiahuai, Ulevitch, Richard J
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Experimental data
Humans
Immune system
Immunity, Innate - genetics
Immunology
Infectious Diseases
Inflammation - drug therapy
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
review-article
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Summary:The idea of the importance of mounting an inflammatory response for effective immunity is supported by a multiplicity of experimental data. It is also well understood that resolution of inflammation is essential for maintaining the balance between health and disease. When the normal regulatory mechanisms are disturbed, the potential for developing chronic inflammatory diseases is increased. Inflammation is a key element in the response of the innate immune system to a variety of challenges, including those provided by bacterial and viral infection as well as by damaged or dying host cells. Here we review elements of innate immunity that lead to inflammation and some of the host mechanisms that allow for the resolution of the inflammatory responses.
ISSN:1529-2908
1529-2916
1365-2567
DOI:10.1038/ni1274